Silicon nitride, an emerging bioceramic material, is highly sought after in the biomedical industry due to its osteogenesis-promoting properties, which are a result of its unique surface chemistry and excellent mechanical properties. Currently, it is used in clinics as an orthopedic implant material. The osteogenesis-promoting properties of silicon nitride are manifested in its contribution to the formation of a local osteogenic microenvironment, wherein silicon nitride and its hydrolysis products influence osteogenesis by modulating the biological behaviors of the constituents of the osteogenic microenvironment. In particular, silicon nitride regulates redox signaling, cellular autophagy, glycolysis, and bone mineralization in cells involved in bone formation several mechanisms. Moreover, it may also promote osteogenesis by influencing immune regulation and angiogenesis. In addition, the wettability, surface morphology, and charge of silicon nitride play crucial roles in regulating its osteogenesis-promoting properties. However, as a bioceramic material, the molding process of silicon nitride needs to be optimized, and its osteogenic mechanism must be further investigated. Herein, we summarize the impact of the molding process of silicon nitride on its osteogenic properties and clinical applications. In addition, the mechanisms of silicon nitride in promoting osteogenesis are discussed, followed by a summary of the current gaps in silicon nitride mechanism research. This review, therefore, aims to provide novel ideas for the future development and applications of silicon nitride.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d3bm00877k | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nanosecond Nanothermometry in an Electron Microscope.
Nano Lett
January 2025
University Paris-Saclay, CNRS, Laboratoire de Physique des Solides, Orsay 91405, France.
Thermal transport in nanostructures plays a critical role in modern technologies. As devices shrink, techniques that can measure thermal properties at nanometer and nanosecond scales are increasingly needed to capture transient, out-of-equilibrium phenomena. We present a novel pump-probe photon-electron method within a scanning transmission electron microscope (STEM) to map temperature dynamics with unprecedented spatial and temporal resolutions.
View Article and Find Full Text PDFWe present both experimental and simulation results for a fully etched, C-band GC fabricated in an 800 nm silicon nitride platform that significantly reduces backreflections. They are minimized by truncating the initial grates, which deflect reflected light at an oblique angle and excite higher-order modes in the tapered waveguide that is filtered out. Insertion losses resulting from this modification of the grating coupler are mitigated by an adaptive redesign of the grates that corrects incurred errors in the generated phase front.
View Article and Find Full Text PDFHighly Efficient and achromatic mid-infrared silicon nitride meta-lenses.
Sci Rep
January 2025
Department of Physics, The American University in Cairo, New Cairo, 11835, Egypt.
Inverse design with topology optimization considers a promising methodology for discovering new optimized photonic structure that enables to break the limitations of the forward or the traditional design especially for the meta-structure. This work presents a high efficiency mid infra-red imaging photonics element along mid infra-red wavelengths band starts from 2 to 5 µm based on silicon nitride optimized material structures. The first two designs are broadband focusing and reflective meta-lens under very high numerical aperture condition (NA = 0.
View Article and Find Full Text PDFExtracorporeal Membrane Oxygenation (ECMO) serves as a crucial intervention for patients with severe pulmonary dysfunction by facilitating oxygenation and carbon dioxide removal. While traditional ECMO systems are effective, their large priming volumes and significant blood-contacting surface areas can lead to complications, particularly in neonates and pediatric patients. Microfluidic ECMO systems offer a promising alternative by miniaturizing the ECMO technology, reducing blood volume requirements, and minimizing device surface area to improve safety and efficiency.
View Article and Find Full Text PDFScaling Behavior of Ionic Conductance Dependent on Surface Charge Inside a Single-Digit Nanopore.
Molecules
January 2025
School of Mechanical Engineering, Chongqing Three Gorges University, Chongqing 404100, China.
Article Synopsis
- The ionic conductance in charged nanopores exhibits a power-law behavior at low salinity, influenced by surface charges that affect zeta potential and ion distributions.
- Accurately measuring surface charge density in single-digit nanopores poses challenges, leading researchers to develop new methodologies to investigate these effects.
- Through experiments with silicon nitride nanopores, a modified conductance model was established to analyze the relationship between pore concentration, surface charges, and potential leakage, allowing for a better understanding of ion mobility in nanopores.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!