AI Article Synopsis
- - Complement signaling helps microglia, which are brain cells, clean up and remove unnecessary connections in the brain, a process known as synaptic pruning.
- - Scientists studied mice without a special receptor called Complement receptor 3 to see how it affected the pruning process in their brains.
- - They found that these mice didn't have problems with synaptic pruning but struggled to eliminate some neurons during a crucial time, leading to thicker brain areas and stronger brain connections later on.
Article Abstract
Complement signaling is thought to serve as an opsonization signal to promote the phagocytosis of synapses by microglia. However, while its role in synaptic remodeling has been demonstrated in the retino-thalamic system, it remains unclear whether complement signaling mediates synaptic pruning in the brain more generally. Here we found that mice lacking the Complement receptor 3, the major microglia complement receptor, failed to show a deficit in either synaptic pruning or axon elimination in the developing mouse cortex. Instead, mice lacking Complement receptor 3 exhibited a deficit in the perinatal elimination of neurons in the cortex, a deficit that is associated with increased cortical thickness and enhanced functional connectivity in these regions in adulthood. These data demonstrate a role for complement in promoting neuronal elimination in the developing cortex.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629900 | PMC |
| http://dx.doi.org/10.1093/cercor/bhad313 | DOI Listing |
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