AI Article Synopsis
- The review focuses on identifying new reliable and non-invasive diagnostic methods for biliary atresia (BA) to expedite diagnosis and subsequent surgical treatment.
- Researchers highlight several promising biomarkers beyond those currently used in neonatal wards, including circulating microRNAs, matrix metalloproteinase-7, and various cytokines.
- The potential diagnostic techniques discussed encompass a range of markers, including urinary metabolites and specific proteins, which could significantly enhance the early detection of BA.
Article Abstract
The aim of this review is to specify new potential reliable and non-invasive methods for the diagnosis of biliary atresia (BA) that could shorten the way to diagnose BA, and finally the surgical treatment. Apart from the biomarkers that have been proven helpful and are used nowadays in neonatal wards, there are several new potential biomarkers that researchers have found to be helpful in the diagnosis of biliary atresia. Circulating microRNAs, matrix metalloproteinase-7, stool proteins, interleukin-33, Th17-associated cytokines, urinary metabolomics, anti-smooth muscle antibodies, heat shock proteins 90 and positive biliary epithelial cells CD56 are among those presented in this summary. These markers may play a new significant role in BA diagnosis. The described methods include Nomogram, Circulating microRNAs (miRNAs), Matrix metalloproteinase-7 (MMP-7), Stool proteins, Interleukin-33 (IL-33), Th17-associated cytokines, Alpha-aminoadipic acid and N-acetyl-d-mannosamine in urine, Anti-smooth muscle antibodies (ASMA), Heat shock proteins 90 (HSP90), Positive biliary epithelial cells CD56.
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| http://dx.doi.org/10.18388/abp.2020_6858 | DOI Listing |
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