Objectives: To evaluate the physiochemical properties and apatite-forming ability of a newly prepared nano-tricalcium silicate-58s bioactive glass-based endodontic sealer (CS-BG-P) and compare its results with the Nishika BG canal sealer and BioRoot™ RCS.
Methods: The physicochemical properties (setting time, flow, solubility, film thickness, and radiopacity) of CS-BG-P, Nishika BG canal sealer, and BioRoot™ RCS were evaluated in accordance with ANSI/ADA 57/2000 (reaffirmed 2012) and ISO 6876:2012 for root canal sealing materials. The in vitro apatite-forming ability was evaluated after 28 days of immersion of disc-shaped specimens in phosphate-buffered saline (PBS) using field emission scanning electron microscopy and energy-dispersive X-ray spectroscopy.
Results: The results of physiochemical tests indicated that all the tested sealers complied with the ADA and ISO standards; however, the solubility of the BioRoot did not meet the two standards. CS-BG-P revealed significantly superior properties in all physicochemical tests compared to Nishika and BioRoot; however, the solubility of Nishika was significantly lower than that of CS-BG-P. Furthermore, all tested sealers exhibited apatite precipitation on their surfaces after 28 days of immersion in PBS.
Conclusions: CS-BG-P had superior physicochemical properties, which mitigated the disadvantages of calcium silicate-based sealers. Moreover, it exhibited apatite precipitation after immersion in PBS. Further in vivo studies utilizing animal models or clinical studies are necessary to support the rationale of the newly developed sealer for clinical application.
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http://dx.doi.org/10.1016/j.job.2023.09.004 | DOI Listing |
J Prosthodont
January 2025
Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Purpose: Few studies have explored the bone response in dental implant sites prepared using a piezoelectric device, indicating moderate effectiveness in enhancing secondary stability and osteogenesis. This study seeks to expand our understanding of the changes in biological, clinical, and radiographic parameters, during the initial phases of osseointegration in sites prepared with piezoelectric surgery.
Materials And Methods: Two implant sites were prepared in the tibia of four minipigs.
Sci Rep
January 2025
Department of Chemistry, Faculty of Science, Arak University, Arak, 38481-77584, Iran.
In this study, a novel hybrid nanostructure consisting of acid-decorated chitosan and magnetic AlFeO nanoparticles was fabricated. The acid-decorated chitosan provided a stable and biocompatible matrix for the magnetic AlFeO nanoparticles. Various techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), specific surface area (BET), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) were used to characterize and confirm the successful synthesis of the hybrid nanostructure.
View Article and Find Full Text PDFTransfus Apher Sci
January 2025
Medical Laboratory Technologist, Dept. of Transfusion Medicine & Blood Centre, AIIMS Kalyani, West Bengal 741245, India.
Introduction: The Reveos automated blood processing system is the only system developed till date, which can separate whole blood into components on complete automation. Their proprietary LR and NLR blood collection sets have their own advantages and disadvantages. Using LR sets, leukodepleted components can be prepared but individual platelet units cannot be prepared.
View Article and Find Full Text PDFBMC Bioinformatics
January 2025
School of Computer Science and Technology, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, China.
Background: Drug-drug interactions (DDIs) especially antagonistic ones present significant risks to patient safety, underscoring the urgent need for reliable prediction methods. Recently, substructure-based DDI prediction has garnered much attention due to the dominant influence of functional groups and substructures on drug properties. However, existing approaches face challenges regarding the insufficient interpretability of identified substructures and the isolation of chemical substructures.
View Article and Find Full Text PDFActa Trop
January 2025
Centre of Excellence for Pharmaceutical Sciences (Pharmacen(TM)), North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:
Praziquantel is currently the only effective treatment for schistosomiasis, but several limitations underscore the need for new therapeutic agents. Recent promising in vitro results with Artemisia species and the success of A. annua and its active compound artemisinin in treating parasitic infections warrant the need for further studies.
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