Background: Supraventricular tachycardias (SVTs), despite having various anatomical substrates and pathophysiological mechanisms, frequently show similar electrocardiographic presentations.

Objectives: To locate and characterize atrial deflections (ADs) on 12-lead electrocardiograms in dogs with sustained rapid SVT and assess the utility of different electrocardiographic variables in differentiating types of tachycardia.

Animals: Ninety-two dogs with orthodromic atrioventricular reciprocating tachycardia, 17 with atrial flutter, 33 with focal atrial tachycardia recorded and confirmed by electrophysiological study, and 40 dogs with sinus tachycardia.

Methods: Atrial deflection position on the 12-lead surface electrocardiogram was assessed according to the sequence of intracardiac activation. Its features were evaluated together with the relationship between AD and QRS complex interval (AD-R) and QRS complex and AD interval (R-AD).

Results: Orthodromic atrioventricular reciprocating tachycardia was characterized by an AD-AD interval of 213 ± 30 ms, mean electrical axis (MEA) of AD of -90 (-90/-78)°, R-AD interval of 75 (65-80) ms, and R-AD/AD-R of 0.54 (0.45-0.64). Atrial flutter was characterized by an AD-AD interval of 199 ± 57 ms, MEA of 76° (72/81), R-AD of 120 (72-144) ms, and R-AD/AD-R of 0.81 (0.63-1.13). Focal atrial tachycardia was characterized by an AD-AD interval of 270 ± 38 ms, MEA of 49 (-72/76)°, R-AD of 160 (120-200) ms, and R-AD/AD-R of 1.45 (0.92-1.67). Sinus tachycardia was characterized by an AD-AD interval of 292 ± 31 ms, MEA of 66° (52/73), R-AD of 215 (192-222) ms, and R-AD/AD-R of 2.68 (2.25-3.08).

Conclusions And Clinical Importance: Analyzing AD on 12-lead electrocardiogram is helpful in differentiating the most common SVTs in dogs.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658594PMC
http://dx.doi.org/10.1111/jvim.16845DOI Listing

Publication Analysis

Top Keywords

characterized ad-ad
16
ad-ad interval
16
tachycardia characterized
12
surface electrocardiogram
8
orthodromic atrioventricular
8
atrioventricular reciprocating
8
reciprocating tachycardia
8
atrial flutter
8
focal atrial
8
atrial tachycardia
8

Similar Publications

Aims: Atherogenic dyslipidemia (AD) is regarded as a residual risk of cardiovascular diseases characterized by low high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) levels and related to the intracranial stenosis of atheromatous thrombotic brain infarction (ATBI). Further, atherosclerosis is possibly related to another stroke subtype, including cryptogenic stroke (CS). In particular, an aortic complicated lesion (ACL) is a notable embolic source of CS, since recurrence of aortogenic brain embolism is not rare.

View Article and Find Full Text PDF

Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer's disease, dementia with Lewy bodies and vascular dementia.

Acta Neuropathol

December 2024

Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Liebigstraße 19, 04103, Leipzig, Germany.

Article Synopsis
  • - The study investigated the role of various post-translational modifications of amyloid-β (Aβ) in different types of dementia, highlighting how specific Aβ variants could characterize distinct dementia forms, including Alzheimer's disease (AD) and other dementias like Lewy body dementia and vascular dementia.
  • - Researchers analyzed post-mortem brain tissues using immunohistochemical techniques and machine learning to quantify various Aβ modifications, finding that AD tissues had the highest levels of Aβ variants compared to other conditions.
  • - Notably, the isoAsp7-Aβ variant was found abundantly across all dementia types, while other modifications displayed varying distributions in plaque types and cerebral blood vessels, with some variants detected intraneuronally rather
View Article and Find Full Text PDF

Introduction: Biomarkers for Alzheimer's disease neuropathologic change (ADNC) have been instrumental in developing effective disease-modifying therapeutics. However, to prevent/treat dementia effectively, we require biomarkers for non-AD neuropathologies; for this, neuropathologic examinations and annotated tissue samples are essential.

Methods: We conducted clinicopathologic correlation for the first 100 Alzheimer's Disease Neuroimaging Initiative (ADNI) Neuropathology Core (NPC) cases.

View Article and Find Full Text PDF
Article Synopsis
  • - Atopic dermatitis (AD) is a common chronic skin condition, but there is currently no effective way to predict which newborns are at risk for developing it.
  • - A study evaluated specific serological biomarkers in 40 newborns to see if they could predict the development of AD, using measurements from cord blood and skin assessments at various ages.
  • - Findings indicated that infants who developed AD showed significantly higher levels of certain biomarkers at birth, suggesting potential predictive indicators for the condition.
View Article and Find Full Text PDF

Introduction: The recent introduction of seed amplification assays (SAAs) detecting misfolded α-synuclein, a pathology-specific marker for Lewy body disease (LBD), has allowed the in vivo identification and phenotypic characterization of patients with co-occurring Alzheimer's disease (AD) and LBD since the early clinical or even preclinical stage.

Methods: We reviewed studies with an in vivo biomarker-based diagnosis of AD-LBD copathology.

Results: Studies in large cohorts of cognitively impaired individuals have shown that cerebrospinal fluid (CSF) biomarkers detect the coexistence of AD and LB pathology in approximately 20%-25% of them, independently of the primary clinical diagnosis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!