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High levels of maternally derived antibodies do not significantly interfere with the development of humoral and cell-mediated responses to Porcine circovirus 2 after intradermal vaccination. | LitMetric

AI Article Synopsis

  • - The study investigated how maternally derived antibodies (MDA) affect the immune response in pigs vaccinated against Porcine circovirus type 2 (PCV2) around weaning, specifically focusing on a controlled farm setting.
  • - After vaccinating piglets at either 21 or 28 days of age, researchers found that those with high or low MDA levels developed similar antibody responses, while unvaccinated controls showed declining antibodies over time.
  • - The results indicate that high MDA levels do not hinder the immune response to PCV2 vaccination, suggesting that timing of vaccination is flexible between 21 and 28 days without affecting effectiveness.

Article Abstract

Background: Vaccination of pigs against PCV2 is usually performed around weaning when animals still have maternally derived antibodies (MDA). The present study aimed to assess the possible interference of MDA in the development of the PCV2-specific immune response after vaccination of commercial weaners. For this purpose, a PRRS-negative 600-sow farrow-to-finish farm was selected. Half of the sows were vaccinated and revaccinated with Porcilis® PCV ID against PCV2 7 and 3 weeks before farrowing. After farrowing, piglets were tested by AlphaLisa to select 72 animals with high and low levels of MDA. Groups were further subdivided and vaccinated intradermally with Porcilis® PCV ID at 21 or 28 days of age. Unvaccinated controls were also included. Animals were followed afterward for 42 days to examine the development of PCV2-specific antibodies and interferon-γ secreting cells (IFN-γ SC).

Results: The average titres of antibodies of the groups vaccinated in the presence of low or high MDA levels were similar at 28 and 42 days post-vaccination while in the controls the titres declined throughout the observation period. Results of vaccinating at 21 or 28 days of age were equivalent with regard to antibody development. Regarding the IFN-γ SC, vaccinated animals produced significant frequencies of IFN-γ SC by day 28. Again, no differences were observed between the groups with high or low antibody levels.

Conclusion: High levels of MDA did not interfere with the development of humoral and cell-mediated responses to Porcine circovirus 2 after intradermal vaccination at 21 or 28 days of age.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503209PMC
http://dx.doi.org/10.1186/s40813-023-00335-9DOI Listing

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