In music and language domains, it has been suggested that patterned transitions of sounds can be acquired implicitly through statistical learning. Previous studies have investigated the statistical learning of auditory regularities by recording early neural responses to a sequence of tones presented at high or low transition probabilities. However, it remains unclear whether the statistical learning of musical chord transitions is reflected in endogenous, regularity-dependent components of the event-related potential (ERP). The present study aimed to record the mismatch negativity (MMN) elicited by chord transitions that deviated from newly learned transitional regularities. Chords were generated in a novel 18 equal temperament pitch class scale to avoid interference from the existing tonal representations of the 12 equal temperament pitch class system. Thirty-six adults without professional musical training listened to a sequence of randomly inverted chords in which certain chords were presented with high (standard) or low (deviant) transition probabilities. An irrelevant timbre change detection task was assigned to make them attend to the sequence during the ERP recording. After that, a familiarity test was administered in which the participants were asked to choose the more familiar chord sequence out of two successive sequences. The results showed that deviant transitions elicited the MMN, although the participants could not recognize the standard transition beyond the level of chance. These findings suggest that humans can statistically learn new transitional regularities of chords in a novel musical scale, even though they did not recognize them explicitly. This study provides further evidence that music-syntactic regularities can be acquired implicitly through statistical learning.
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http://dx.doi.org/10.1016/j.neulet.2023.137478 | DOI Listing |
Sci Rep
January 2025
Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, India.
We have adopted the classification Read-Across Structure-Activity Relationship (c-RASAR) approach in the present study for machine-learning (ML)-based model development from a recently reported curated dataset of nephrotoxicity potential of orally active drugs. We initially developed ML models using nine different algorithms separately on topological descriptors (referred to as simply "descriptors" in the subsequent sections of the manuscript) and MACCS fingerprints (referred to as "fingerprints" in the subsequent sections of the manuscript), thus generating 18 different ML QSAR models. Using the chemical spaces defined by the modeling descriptors and fingerprints, the similarity and error-based RASAR descriptors were computed, and the most discriminating RASAR descriptors were used to develop another set of 18 different ML c-RASAR models.
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January 2025
Department of Computer Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand.
Active transportation, such as cycling, improves mobility and general health. However, statistics reveal that in low- and middle-income countries, male and female cycling participation rates differ significantly. Existing literature highlights that women's willingness to use bicycles is significantly influenced by their perception of security.
View Article and Find Full Text PDFNat Commun
January 2025
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Spatial protein expression technologies can map cellular content and organization by simultaneously quantifying the expression of >40 proteins at subcellular resolution within intact tissue sections and cell lines. However, necessary image segmentation to single cells is challenging and error prone, easily confounding the interpretation of cellular phenotypes and cell clusters. To address these limitations, we present STARLING, a probabilistic machine learning model designed to quantify cell populations from spatial protein expression data while accounting for segmentation errors.
View Article and Find Full Text PDFNat Commun
January 2025
Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture and Rural Affairs & Fisheries college, Jimei University, Xiamen, Fujian, People's Republic of China.
Deep phenotyping can enhance the power of genetic analysis, including genome-wide association studies (GWAS), but the occurrence of missing phenotypes compromises the potential of such resources. Although many phenotypic imputation methods have been developed, the accurate imputation of millions of individuals remains challenging. In the present study, we have developed a multi-phenotype imputation method based on mixed fast random forest (PIXANT) by leveraging efficient machine learning (ML)-based algorithms.
View Article and Find Full Text PDFBMC Musculoskelet Disord
January 2025
Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Background: To summarize the statistical performance of machine learning in predicting revision, secondary knee injury, or reoperations following anterior cruciate ligament reconstruction (ACLR), and to provide a general overview of the statistical performance of these models.
Methods: Three online databases (PubMed, MEDLINE, EMBASE) were searched from database inception to February 6, 2024, to identify literature on the use of machine learning to predict revision, secondary knee injury (e.g.
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