AI Article Synopsis
- Research investigates the impact of inhaled corticosteroids (ICS) and biologics on the immune response to mRNA COVID-19 vaccination in asthma patients.
- The study involved 30 patients, measuring immune markers at 3 weeks and 6 months after their second vaccine dose, finding no significant differences between those on biologics and those not.
- Key factors like age and sex affected immune response, but ICS and biologics didn't seem to influence vaccine effectiveness; further research is needed for confirmation.
Article Abstract
The effect of inhaled corticosteroids (ICS) and biologics on the humoral immune response following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination in patients with asthma is unknown. We prospectively evaluated the humoral immune response 3 weeks (T1) and 6 months (T2) after the second dose of BNT162b2 in 30 SARS-CoV-2-naïve patients with asthma. We measured anti-spike immunoglobulin G (IgG) titers and serum-neutralizing activity against the ancestral SARS-CoV-2 strain. The anti-spike IgG titer and neutralizing activity did not differ significantly between the biologics and non-biologics groups at T1 (P = 0.708 and P = 0.417, respectively) or T2 (P = 0.299 and P = 0.492, respectively). In the multivariate analysis, age and sex were significantly associated with the magnitude of the humoral immune response; however, the use of biologics and ICS dose were not, suggesting that these would not affect BNT162b2 immunogenicity in patients with asthma. Larger studies are needed to validate these findings.
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| http://dx.doi.org/10.1016/j.resinv.2023.07.006 | DOI Listing |
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