Purpose: Developmental language disorder (DLD) is characterized by persistent and unexplained difficulties in language development. Accumulating evidence shows that children with DLD also present with deficits in other cognitive domains, such as executive functioning (EF). There is an ongoing debate on whether exclusively verbal EF abilities are impaired in children with DLD or whether nonverbal EF is also impaired, and whether these EF impairments are related to their language difficulties. The aims of this study were to (a) compare nonverbal performance of preschoolers with DLD and typically developing (TD) peers, (b) examine how nonverbal EF and language abilities are related, and (c) investigate whether a diagnosis of DLD moderates the relationship between EF and language abilities.
Method: A total of 143 children ( = 65, = 78) participated. All children were between 3 and 6.5 years old and were monolingual Dutch. We assessed nonverbal EF with a visual selective attention task, a visuospatial short-term and working memory task, and a task gauging broad EF abilities. Vocabulary and morphosyntax were each measured with two standardized language tests. We created latent variables for EF, vocabulary, and morphosyntax.
Results: Analyses showed that children with DLD were outperformed by their TD peers on all nonverbal EF tasks. Nonverbal EF abilities were related to morphosyntactic abilities in both groups, whereas a relationship between vocabulary and EF skills was found in the TD group only. These relationships were not significantly moderated by a diagnosis of DLD.
Conclusions: We found evidence for nonverbal EF impairments in preschool children with DLD. Moreover, nonverbal EF and morphosyntactic abilities were significantly related in these children. These findings may have implications for intervention and support the improvement of prognostic accuracy.
Supplemental Material: https://doi.org/10.23641/asha.24121287.
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http://dx.doi.org/10.1044/2023_JSLHR-22-00732 | DOI Listing |
Brain Behav
December 2024
Department of Audiology, Faculty of Health Sciences, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Background: The aim was to compare the sensory processing skills of children diagnosed with developmental language disorder (DLD) with those of typically developing children and to investigate the relationship between language development and sensory processing skills.
Methods: The investigation comprised 60 children, all of whom were typically developing and diagnosed with DLD. The "Early Language Development-Third: Turkish (ELD: Turkish)" and the "Sensory Profile (Caregiver Questionnaire)" were utilized to assess the language and sensory processing skills of the children, respectively, within the scope of the study.
J Exp Child Psychol
December 2024
Child Psychopathology Unit, Scientific Institute, 23842 Bosisio Parini, Lecco, Italy.
The ability to process auditory information is one of the foundations of the ability to appropriately acquire language. Moreover, early difficulties in basic auditory abilities have cascading effects on the appropriate wiring of brain networks underlying higher-order linguistic processes. Language impairments represent core difficulties in two different but partially overlapping disorders: developmental language disorder (DLD) and autism spectrum disorder (ASD).
View Article and Find Full Text PDFClin Linguist Phon
December 2024
Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Children with developmental language disorder (DLD) are poor at story-telling and show weaknesses in various executive functions (EFs). Narrative tasks are frequently used in clinical assessment to capture the linguistic vulnerabilities of individuals with DLD. But we know little about the demands of different narrative tasks on EFs.
View Article and Find Full Text PDFMol Ther
November 2024
Department of Oncology, Hematology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, 72076 Tuebingen, Germany; Gene and RNA Therapy Center (GRTC), Tuebingen University, 72076 Tuebingen, Germany. Electronic address:
Severe congenital neutropenia (CN) patients require life-long treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF), but some show no response. We sought to establish a therapy for CN that targets signaling pathways causing maturation arrest of granulocytic progenitors. We developed an isogenic induced pluripotent stem cell (iPSC) in vitro model of CN associated with ELANE mutations (ELANE-CN) and performed an in silico drug repurposing analysis of the transcriptomics of iPSC-generated hematopoietic stem and progenitor cells.
View Article and Find Full Text PDFInt J Lang Commun Disord
December 2024
Curtin School of Allied Health and Curtin enAble Institute, Curtin University, Bentley, Western Australia, Australia.
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