Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503703PMC
http://dx.doi.org/10.1371/journal.pbio.3002295DOI Listing

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