AI Article Synopsis
- The study aimed to assess oral health and quality of life related to oral health (OHRQoL) in patients receiving antiresorptive therapy (ART) during supportive periodontal care (SPC), focusing on the impact of medication-related osteonecrosis of the jaw (MRONJ).
- A total of 100 patients were evaluated, half receiving ART and the other half not, with findings indicating that those on ART had a significantly higher OHRQoL score despite similar overall dental health and periodontal conditions.
- It was concluded that while patients on ART had comparable clinical metrics to those off ART, they experienced lower OHRQoL, highlighting the need for increased awareness about MRONJ risks and preventive measures.
Article Abstract
Objectives: To investigate oral health and oral health-related quality of life (OHRQoL) of patients under antiresorptive therapy (ART) during supportive periodontal care (SPC) considering history of medication-related osteonecrosis of the jaw (MRONJ).
Materials And Methods: In this cross-sectional study, 100 patients (50 receiving ART (exposed) and 50 without ART (unexposed)) in regular SPC were enrolled for a clinical oral examination and the evaluation of OHRQoL using the OHIP-G14-questionnaire. History of MRONJ was assessed by anamnesis and reviewing patient records.
Results: There were no statistically significant group differences in age (exposed: 70.00 ± 9.07 versus unexposed: 71.02 ± 8.22 years), sex, distribution of systemic diseases and duration of SPC (on average 8.61 ± 5.73 years). Number of teeth (21.02 ± 5.84 versus 21.40 ± 5.42), DMFT (18.38 ± 3.85 versus 17.96 ± 4.08), probing pocket depth (2.31 ± 0.20 versus 2.38 ± 0.26), clinical attachment level (3.25 ± 0.76 versus 3.46 ± 0.58) and bleeding on probing (15.07 ± 11.53 versus 15.77 ± 13.08) were also not significantly different. The OHIP-G14 sum-score was significantly higher in exposed participants (6.10 ± 6.76 versus 3.62 ± 5.22, p = 0.043). History of MRONJ was prevalent in 8% of patients under ART. Periodontal/peri-implant-related MRONJ were reported in three participants with cancer (n = 1 before and n = 2 after active periodontal therapy). History of MRONJ due to endodontic/restorative reasons was reported in one patient with osteoporosis.
Conclusions: Patients under ART in SPC demonstrated similar clinical periodontal and dental status but lower OHRQoL compared to unexposed (not statistically significant). Patient awareness of the MRONJ-risk and appropriate preventive measures should be ensured.
Clinical Relevance: SPC in osteoporotic patients under ART appeared safe regarding MRONJ, but further investigations on the MRONJ-risk in patients with different risk-profiles are necessary.
Study Registration: clinicaltrials.gov (#NCT04192188).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630227 | PMC |
| http://dx.doi.org/10.1007/s00784-023-05257-y | DOI Listing |
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