Two oxygenated ergostane-type steroids including one new compound, 3-hydroxy-5,6-methoxyergosta-7,22-dien-15-one () along with a known analogue ergosta-6,22-dien-3,5,8-triol () were isolated from the crude extracts of the marine sponge-derived fungus sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound exhibited antibacterial activity against
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