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IgE-mediated flaxseed allergy in non-atopic toddler polysensitized to tree nuts but tolerating other seeds.
Eur Ann Allergy Clin Immunol
September 2024
Department of Pediatrics, Division of Pediatric Allergy and Immunology, Holtz Children's Hospital at Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami (FL), U.S.A.
Anti-allergic property of dietary phytoestrogen secoisolariciresinol diglucoside through microbial and β-glucuronidase-mediated metabolism.
J Nutr Biochem
February 2023
Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan; Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, NIBIOHN; Graduate School of Medicine, Graduate School of Science and Graduate School of Dentistry, Osaka University, Osaka, Japan; Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:
Phytoestrogens play pivotal roles in controlling not only the endocrine system but also inflammatory metabolic disorders. However, the effects of dietary phytoestrogens on allergic diseases and underlying mechanisms remain unclear. In this study, we revealed the unique metabolic conversion of phytoestrogen to exert anti-allergic properties, using an ovalbumin-induced allergic rhinitis mouse model.
View Article and Find Full Text PDFAssociation Between the Seed Storage Proteins 2S Albumin and 11S Globulin and Severe Allergic Reaction After Flaxseed Intake.
J Investig Allergol Clin Immunol
October 2022
Department of Biochemistry and Molecular Biology, Chemistry Faculty, Complutense University of Madrid, Madrid, Spain.
Background: Given the increased popularity of flaxseed in meals, several cases of allergy to these seeds have been reported. Little is known about the allergens implicated in hypersensitivity reactions to flaxseed. The present study aimed to identify the allergens involved in IgE-mediated reactions in 5 patients with a clinical history of severe systemic symptoms after flaxseed consumption.
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