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No Bacterial Biomass Detected in Tissue From Patients With Ovarian Cancer and Serous Tubal Intraepithelial Carcinomas Using 16S rDNA Sequencing.
APMIS
January 2025
Department of Pathology, Herlev and Gentofte University Hospital, Herlev, Denmark.
The ovarian oncobiome is subject to increasing scientific focus, but a potential link between bacterial dysbiosis and ovarian carcinogenesis remains controversial. Our primary aim was to characterize the bacterial microbiota in epithelial ovarian cancer samples. Secondarily, we aimed to compare results from the bacterial microbiota in formalin-fixed, paraffin-embedded ovarian tissue samples from 194 patients with epithelial ovarian cancer, fallopian tube tissue samples from 16 patients with serous tubal intraepithelial carcinomas and in benign fallopian tube tissue samples from 25 patients.
View Article and Find Full Text PDFLactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model.
APMIS
January 2025
Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)-derived halogenated furanones, which act to block the QS pathway, against key fungal pathogens of the skin (Candida albicans, Malassezia furfur and Microsporum gypseum). Moreover, we aimed to assess how these actives performed against complex interkingdom biofilms in a clinically relevant model.
View Article and Find Full Text PDFPhylogeogenomic analysis of the earliest reported sequences of SARS-CoV-2 from 161 countries.
APMIS
January 2025
Clinical and Applied Genomics (CAG) Laboratory, Department of Biological Sciences, Aliah University, Kolkata, India.
Article Synopsis
- The study examines the evolutionary development of SARS-CoV-2, the virus behind COVID-19, across 161 countries using genetic sequences downloaded from the GISAID database.
- The analysis focused on multiple proteins, finding that NSP3 and NSP12 showed the highest mutation rates among non-structural proteins, while the spike (S) protein had the most mutations overall.
- The research identified a phylogeogenomic network with distinct haplogroups, revealing higher genetic variations in European sequences and suggesting that the virus's spread originated from Asia, highlighting various transmission pathways that led to its global emergence by early 2020.
APMIS focus issue 2024-The microenvironment in human disease.
APMIS
December 2024
Department of Clinical Microbiology, Copenhagen University Hospital.
Article Synopsis
- Endotoxemia is linked to various diseases, and the gut microbiota plays a crucial role as it acts as a major reservoir of endotoxins in the body.
- Dysbiosis in the gut microbiota can lead to increased intestinal permeability and bacterial translocation, contributing to endotoxemia.
- The Mediterranean diet is highlighted as beneficial for gut health, potentially regulating the microbiota and supporting intestinal barrier function to mitigate endotoxemia.
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