Sagittal computed tomography of lumbal spine showing dural ectasia and Tarlow Cyst (red arrows) (A). Magnetic resonance imaging (MRI) axial slice, susceptibility-weighted imaging (SWI) sequences showing siderosis in cerebellar sulci (red arrows) and in the inset uncharacteristic iron deposition in dental nuclei, more pronounced on the left side (red arrows) (B, inset). MRI, SWI, axial slice, showing numerous foci of superficial siderosis (C).
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http://dx.doi.org/10.1002/cdt3.63 | DOI Listing |
Gynecol Oncol
January 2025
Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Introduction: Molecular alterations in the PI3K/AKT and Ras/Raf/MEK/ERK pathways are frequently observed in patients with endometrial cancers. However, mTOR inhibitors, such as temsirolimus, have modest clinical benefits. In addition to inducing metabolic changes in cells, metformin activates AMPK, which in turn inhibits the mTOR pathway.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Stanford University, Stanford, CA, USA
Background: Specimen analysis is crucial for identifying imaging and neuropathological signatures. Histology is the gold‐standard, but sample preparation and sectioning induce tissue deformations which hinder quantitative analysis or registration of histology to 3D MRI providing a challenge to the development of MRI biomarkers. Overall, we aim to develop a workflow to correlate histology with high‐resolution MRI at a microscopic level (Figure 1), Here, we evaluate a critical step in this process ‐ the section quality from tissue mounting techniques, comparing: A) traditional water bath (Figure 1F), and B) tape transfer (Figure 1G), for the purpose of image segmentation and correlation with high‐resolution MRI.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Stanford University, Stanford, CA, USA
Background: Specimen analysis is crucial for identifying imaging and neuropathological signatures. Histology is the gold‐standard, but sample preparation and sectioning induce tissue deformations which hinder quantitative analysis or registration of histology to 3D MRI providing a challenge to the development of MRI biomarkers. Overall, we aim to develop a workflow to correlate histology with high‐resolution MRI at a microscopic level (Fig.
View Article and Find Full Text PDFClin Nephrol Case Stud
December 2024
Nephrology Center and the Okinaka Memorial Institute for Medical Research.
A 47-year-old woman with a 12-year history of anemia and high C-reactive protein (CRP) levels was admitted to our hospital with worsening fatigue and night sweats. She had high levels of immunoglobulin G (IgG; 4182 mg/dL), IgA (630.6 mg/dL), and CRP (7.
View Article and Find Full Text PDFJ Mol Histol
December 2024
Department of Clinical Laboratory, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan City, 250000, Shandong Province, China.
The purpose of this study was to explore the inhibitory effect of andrographolide on the expression of key regulatory genes involved in the biofilm formation of Staphylococcus epidermidis (SE). Taking the film-producing strain Staphylococcus epidermidis SE1457 as the research object, the effect of andrographolide on the formation of Staphylococcus epidermidis biofilms was analyzed via crystal violet staining, and biofilm models of SE adhesion, aggregation and maturity were established in vitro. RT‒PCR was used to detect the effects of the expression of icaA-, atlE-, aap- and luxS-related genes of andrographolide on biofilm formation in SE.
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