Correction for 'Cyclopentane FIT-PNAs: bright RNA sensors' by Odelia Tepper , , 2021, , 540-543, https://doi.org/10.1039/D0CC07400D.
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School of Pharmacy, Institute for Drug Research, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem 91120, Israel.
Forced intercalation peptide nucleic acids (FIT-PNAs) are DNA mimics that act as RNA sensors. The sensing event occurs due to sequence-specific RNA hybridization, leading to a substantial increase in fluorescence. The fluorophore in the FIT-PNA is termed a surrogate base.
View Article and Find Full Text PDFCorrection: Cyclopentane FIT-PNAs: bright RNA sensors.
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The Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem 91120, Israel.
Correction for 'Cyclopentane FIT-PNAs: bright RNA sensors' by Odelia Tepper , , 2021, , 540-543, https://doi.org/10.1039/D0CC07400D.
View Article and Find Full Text PDFCyclopentane FIT-PNAs: bright RNA sensors.
Chem Commun (Camb)
January 2021
The Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem 91120, Israel.
Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).
View Article and Find Full Text PDFRed-emitting FIT-PNAs: "On site" detection of RNA biomarkers in fresh human cancer tissues.
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July 2019
School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem, 91120, Israel. Electronic address:
To date, there are limited approaches for the direct and rapid visualization (on site) of tumor tissues for pathological assessment and for aiding cytoreductive surgery. Herein, we have designed FIT-PNAs (forced-intercalation-peptide nucleic acids) to detect two RNA cancer biomarkers. Firstly, a lncRNA (long noncoding RNA) termed CCAT1, has been shown as an oncogenic lncRNA over-expressed in a variety of cancers.
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