We have investigated the incorporation of an AlGaAs lateral potential barrier layer (LPBL) as a novel approach to improve the temperature stability of the threshold current in InAs/GaAs quantum dot (QD) lasers. This layer serves to increase the energy separation (ΔE) between the ground and excited states of the QD while maintaining efficient vertical carrier injection. Theoretical calculations confirm that the LPBL is effective in increasing ΔE. The LPBLs were successfully formed using the preferential growth properties of AlGaAs induced by the non-uniform distribution of strain effects on the QD surface during molecular beam epitaxy growth. To confirm the usefulness of the LPBLs, we fabricated an InAs/GaAs QD laser incorporating AlGaAs LPBLs, demonstrating that the threshold current at 150°C was significantly reduced by 48% compared to a QD laser without LPBLs. The temperature stabilization achieved by incorporating the LPBLs provides a promising way for establishing high reliability and low power operation of QD lasers in high-temperature environments.
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http://dx.doi.org/10.1364/OE.498996 | DOI Listing |
Clin Chem
January 2025
Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Background: Multianalyte machine learning (ML) models can potentially identify previously undetectable wrong blood in tube (WBIT) errors, improving upon current single-analyte delta check methodology. However, WBIT detection model performance has not been assessed in a real-world, low-prevalence context. To estimate real-world positive predictive values, we propose a methodology to assess WBIT detection models by evaluating the impact of missing data and by using a "low prevalence" validation data set.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-093 Lublin, Poland.
: Temporomandibular disorders (TMDs) represent a significant public health issue, among which masticatory muscle pain is the most common. Current publications increasingly indicate surface electromyography (sEMG) as an effective diagnostic tool for muscle dysfunctions that may be employed in TMDs recognition. The objective of this study was to establish reference ranges for TMDs patients with masticatory muscle pain and healthy individuals in the electromyographic Functional Clenching Index (FCI) for the temporalis muscles (TAs) and masseter muscles (MMs).
View Article and Find Full Text PDFSensors (Basel)
December 2024
Department of Computer and Information Systems, The University of Aizu, Aizuwakamatsu 965-8580, Fukushima, Japan.
In the current era of advanced IoT technology, human occupancy monitoring and positioning technology is widely used in various scenarios. For example, it can optimize passenger flow in public transportation systems, enhance safety in large shopping malls, and adjust smart home devices based on the location and number of occupants for energy savings. Additionally, in homes requiring special care, it can provide timely assistance.
View Article and Find Full Text PDFSensors (Basel)
December 2024
The Department of Information Systems and Computer Science, Ateneo de Manila University, Quezon City 1108, Philippines.
Epilepsy, as a common brain disease, causes great pain and stress to patients around the world. At present, the main treatment methods are drug, surgical, and electrical stimulation therapies. Electrical stimulation has recently emerged as an alternative treatment for reducing symptomatic seizures.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Faculty of Pharmacy, University of Montreal, 2940 Chem. de Polytechnique, Montreal, QC H3T 1J4, Canada.
Background/objectives: Through phase III clinical trials, PARP inhibitors have demonstrated outcome improvements in mCRPC patients with alterations in BRCA1/2 genes who have progressed on a second-generation androgen receptor pathway inhibitor (ARPI). While improving outcomes, PARP inhibitors contribute to the ever-growing economic burden of PCa. The objective of this project is to evaluate the cost-effectiveness of PARP inhibitors (olaparib, rucaparib, or talazoparib) versus the SOC (docetaxel or androgen receptor pathway inhibitors (ARPI)) for previously progressed mCRPC patients with BRCA1/2 mutations from the Canadian healthcare system perspective.
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