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A scATAC-seq atlas of chromatin accessibility in axolotl brain regions. | LitMetric

AI Article Synopsis

  • - Axolotls are a key species for studying regeneration and brain development, but their brain's gene regulatory network is not fully understood.
  • - Researchers used single-cell ATAC sequencing to analyze the chromatin accessibility of over 81,000 cells from various brain regions of the axolotl.
  • - This study identified specific transcription factors for different cell types and sets the stage for deeper insights into axolotl brain evolution, development, and the diversity of cell types in vertebrates.

Article Abstract

Axolotl (Ambystoma mexicanum) is an excellent model for investigating regeneration, the interaction between regenerative and developmental processes, comparative genomics, and evolution. The brain, which serves as the material basis of consciousness, learning, memory, and behavior, is the most complex and advanced organ in axolotl. The modulation of transcription factors is a crucial aspect in determining the function of diverse regions within the brain. There is, however, no comprehensive understanding of the gene regulatory network of axolotl brain regions. Here, we utilized single-cell ATAC sequencing to generate the chromatin accessibility landscapes of 81,199 cells from the olfactory bulb, telencephalon, diencephalon and mesencephalon, hypothalamus and pituitary, and the rhombencephalon. Based on these data, we identified key transcription factors specific to distinct cell types and compared cell type functions across brain regions. Our results provide a foundation for comprehensive analysis of gene regulatory programs, which are valuable for future studies of axolotl brain development, regeneration, and evolution, as well as on the mechanisms underlying cell-type diversity in vertebrate brains.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502032PMC
http://dx.doi.org/10.1038/s41597-023-02533-0DOI Listing

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