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A paradigmatic approach to the topological measure of babesiosis drugs and estimating physical properties via QSPR analysis.
Heliyon
January 2025
College of Since and Art, Department of Mathematics, King Khalid University, Mahayil, Saudi Arabia.
New developments in the field of chemical graph theory have made it easier to comprehend how chemical structures relate to the graphs that underlie them on a more profound level using the ideas of classical graph theory. Chemical graphs can be effectively probed with the help of quantitative structure-property relationship (QSPR) analysis. In order to statistically correlate physical attributes.
View Article and Find Full Text PDFAI Interventions to Alleviate Healthcare Shortages and Enhance Work Conditions in Critical Care: Qualitative Analysis.
J Med Internet Res
January 2025
ETH Zurich, Zurich, Switzerland.
Background: The escalating global scarcity of skilled health care professionals is a critical concern, further exacerbated by rising stress levels and clinician burnout rates. Artificial intelligence (AI) has surfaced as a potential resource to alleviate these challenges. Nevertheless, it is not taken for granted that AI will inevitably augment human performance, as ill-designed systems may inadvertently impose new burdens on health care workers, and implementation may be challenging.
View Article and Find Full Text PDFControversies in implementing the exemption policy for the elderly healthcare services in Tanzania: experiences from the priority setting process in two selected districts.
Cost Eff Resour Alloc
December 2024
Department of Development Studies, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Background: Health financing system in Tanzania changed in the early 1990s as a result of the introduction of cost-sharing policies by the 1990s health sector reforms. The reforms brought about user fees which has led to inequity in access to health care services and catastrophic health expenditure among the elderly. In efforts to reduce the inequity gap among vulnerable groups, in 1994, the government introduced an exemption and waiver policy.
View Article and Find Full Text PDFSodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic pain.
Neurotherapeutics
November 2024
Department of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Peter Hung Pain Research Institute, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address:
Chemotherapy-induced peripheral neuropathy (CIPN) and its related pain are common challenges for patients receiving oxaliplatin chemotherapy. Oxaliplatin accumulation in dorsal root ganglion (DRGs) is known to impair gene transcription by epigenetic dysregulation. We hypothesized that sodium butyrate, a pro-resolution short-chain fatty acid, inhibited histone acetylation in DRGs and abolished K channel dysregulation-induced neuronal hyperexcitability after oxaliplatin treatment.
View Article and Find Full Text PDFHow Artificial Intelligence is altering the nursing workforce.
Nurs Outlook
November 2024
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA.
This paper focuses on the implications of Artificial Intelligence (AI) for the nursing workforce, examining both the opportunities presented by AI in relieving nurses of routine tasks and enabling better patient care, and the potential challenges it poses. The discussion highlights the freeing of nurses' time from administrative duties, allowing for more patient interaction and professional development, while also acknowledging concerns about job displacement. Ethically integrating AI into patient care and the need for nurses' proactive engagement with AI-including involvement in its development and integration in nursing education-are emphasized.
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