Lee et al. report that loss of the Alzheimer's disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and increased Aβ levels and phosphorylated Tau, both rescued by stabilizing retromer or enhancing autophagy.
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| http://dx.doi.org/10.1016/j.celrep.2023.113129 | DOI Listing |
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