Magnetic Resonance Water Tracer Imaging Using 17 O-Labeled Water.

Invest Radiol

From the Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan (H.K., N.K., D.K., T.F., T.H., K.K.); Department of Radiology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Hokkaido, Japan (H.K.); Department of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan (N.K., D.K., T.F., T.H., K.K.); Live Animal Imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan (Y.K.); Faculty of Health Sciences, Hokkaido University, Sapporo, Japan (H.S.); Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan (T. Onodera); Department of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology, Chiba, Japan (M.T., T. Obata); and Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan (T.H., K.K.).

Published: January 2024

Magnetic resonance imaging (MRI) is a crucial imaging technique for visualizing water in living organisms. Besides proton MRI, which is widely available and enables direct visualization of intrinsic water distribution and dynamics in various environments, MR-WTI (MR water tracer imaging) using 17 O-labeled water has been developed, benefiting from the many advancements in MRI software and hardware that have substantially improved the signal-to-noise ratio and made possible faster imaging. This cutting-edge technique allows the generation of novel and valuable images for clinical use. This review elucidates the studies related to MRI water tracer techniques centered around 17 O-labeled water, explaining the fundamental principles of imaging and providing clinical application examples. Anticipating continued progress in studies involving isotope-labeled water, this review is expected to contribute to elucidating the pathophysiology of various diseases related to water dynamics abnormalities and establishing novel imaging diagnostic methods for associated diseases.

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Source
http://dx.doi.org/10.1097/RLI.0000000000001021DOI Listing

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