AI Article Synopsis
- The study aimed to investigate the relationship between psychological resilience and DNA methylation age, using data from 4,018 participants in the Health and Retirement Study.
- Researchers applied multivariable linear regression models to examine this association, controlling for factors like age, sex, and education.
- Results indicated that higher psychological resilience scores were linked to slower DNA methylation age acceleration across most epigenetic clocks, suggesting greater resilience may correlate with slower biological aging.
Article Abstract
The aim of this study was to evaluate the associations between psychological resilience and epigenetic clocks assessed by DNA methylation age predictions. We used data from 4018 participants in the Health and Retirement Study. Multivariable linear regression models were used to estimate the association between psychological resilience and epigenetic clocks adjusted for age, sex, race, body mass index, smoking status, and years of education. Thirteen epigenetic clocks were used in our analysis and were highly correlated with one another. A higher psychological resilience score was associated with slower DNA methylation age acceleration for the majority of epigenetic clocks after multivariable adjustment. These findings imply that people with a higher level of psychological resilience may experience slower DNA methylation age acceleration and biological aging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828333 | PMC |
| http://dx.doi.org/10.1007/s11357-023-00940-0 | DOI Listing |
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