Telescopes measuring cosmic microwave background (CMB) polarization on large angular scales require exquisite control of systematic errors to ensure the fidelity of the cosmological results. In particular, far-sidelobe contamination from wide angle scattering is a potentially prominent source of systematic error for large aperture microwave telescopes. Here we describe and demonstrate a ray-tracing-based modeling technique to predict far sidelobes for a three mirror anastigmat telescope designed to observe the CMB from the South Pole. Those sidelobes are produced by light scattered in the receiver optics subsequently interacting with the walls of the surrounding telescope enclosure. After comparing simulated sidelobe maps and angular power spectra for different enclosure wall treatments, we propose a highly scattering surface that would provide more than an order of magnitude reduction in the degree-scale far-sidelobe contrast compared to a typical reflective surface. We conclude by discussing the fabrication of a prototype scattering wall panel and presenting measurements of its angular scattering profile.
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http://dx.doi.org/10.1364/AO.488454 | DOI Listing |
J Immunother Cancer
January 2025
Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
Purpose: Anti-programmed cell death 1 (PD1) is the first-choice treatment in patients with advanced cutaneous squamous cell carcinoma (cSCC), when curative options are unavailable. However, reliable biomarkers for patient selection are still lacking.
Experimental Design: In this translational study, clinical annotations, tissue and liquid biopsies were acquired to investigate the association between sustained objective responses and transcriptional profiles, immune cell dynamics in tumor tissue and peripheral blood samples, as well as circulating cytokine levels.
J Eval Clin Pract
February 2025
Department of Anatomy, Medical College, Jinan University, Guangdong, China.
Objective: To examine the medical students' awareness of laparoscopic surgery as well as assess the perceived importance of laparoscopic simulation training, and its impact on students' confidence, career aspirations, proficiency, spatial skills, and physical tolerance.
Design: Descriptive and comparative study using pre- and post-training assessments.
Setting: Simulation training sessions centred on laparoscopic surgery techniques.
J Hazard Mater
January 2025
Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, State Key Laboratory of Marine Environmental Science, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem, College of the Environment and Ecology, Xiamen University, Xiamen 361102, China. Electronic address:
Predicting nanoplastic bioaccumulation and toxicity using process-based models is challenging due to the difficulties in tracing them at low concentrations. This study investigates the size-dependent effects of nanoplastic exposure on Daphnia magna using a toxicokinetic-toxicodynamic (TKTD) model. Palladium-doped fluorescent nanoplastics in three sizes (30-nm, 66-nm, 170-nm) were tested at two numeric exposure concentrations.
View Article and Find Full Text PDFDent Mater
January 2025
Department of Restorative Dentistry, University of Manitoba, Winnipeg, MB, R3E 0W2, Canada.
Objective: This study aimed to evaluate the chemical solubility (CS) and conduct a comprehensive physicochemical characterization of several experimental and commercial lithium silicate-based glass-ceramics towards an understanding of the chemical processes governing dissolution in these glass-ceramics.
Methodology: Glass-ceramic (GC) samples were categorized into two groups: experimental materials featuring lithium metasilicate crystals (GCE1 and GCE2); and five commercial brands relying mostly on lithium disilicate (Celtra®Duo, IPS e.max®CAD, Straumann®n!ce®, CEREC Tessera™, and VITA Suprinity®).
Brain Behav
January 2025
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Background: Different modes of motor acquisition, including motor execution (ME), motor imagery (MI), action observation (AO), and mirror visual feedback (MVF), are often used when learning new motor behavior and in clinical rehabilitation.
Purpose: The aim of this study was to investigate differences in brain activation during different motor acquisition modes among healthy young adults.
Methods: This cross-sectional study recruited 29 healthy young adults.
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