AI Article Synopsis
- A malignant tumor in the breast exhibits both spindle cell and chondroid characteristics and has spread to a lymph node.
- The presence of lymph node metastases suggests a metaplastic carcinoma, but this case shows evidence favoring a diagnosis of a malignant phyllodes tumor (MPT).
- Genetic analysis revealed specific mutations in the MED12 gene and TERT gene promoter, providing strong support for the MPT diagnosis.
Article Abstract
A malignant neoplasm with spindle cell and chondroid differentiation in the breast, metastatic to lymph node. In this context, a metaplastic carcinoma is typically favored given the exceptional nature of lymph node metastases in malignant phyllodes tumors (MPT). However, we demonstrate pathognomonic hotspot mutations in MED12 and the promoter of the TERT gene by targeted next-generation DNA sequencing, supporting a diagnosis of MPT.
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| http://dx.doi.org/10.1111/his.15046 | DOI Listing |
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