MSCDNet-based multi-class classification of skin cancer using dermoscopy images.

PeerJ Comput Sci

School of Computer Science Engineering, VIT-AP University, Amaravathi, India.

Published: August 2023

Background: Skin cancer is a life-threatening disease, and early detection of skin cancer improves the chances of recovery. Skin cancer detection based on deep learning algorithms has recently grown popular. In this research, a new deep learning-based network model for the multiple skin cancer classification including melanoma, benign keratosis, melanocytic nevi, and basal cell carcinoma is presented. We propose an automatic Multi-class Skin Cancer Detection Network (MSCD-Net) model in this research.

Methods: The study proposes an efficient semantic segmentation deep learning model "DenseUNet" for skin lesion segmentation. The semantic skin lesions are segmented by using the DenseUNet model with a substantially deeper network and fewer trainable parameters. Some of the most relevant features are selected using Binary Dragonfly Algorithm (BDA). SqueezeNet-based classification can be made in the selected features.

Results: The performance of the proposed model is evaluated using the ISIC 2019 dataset. The DenseNet connections and UNet links are used by the proposed DenseUNet segmentation model, which produces low-level features and provides better segmentation results. The performance results of the proposed MSCD-Net model are superior to previous research in terms of effectiveness and efficiency on the standard ISIC 2019 dataset.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495937PMC
http://dx.doi.org/10.7717/peerj-cs.1520DOI Listing

Publication Analysis

Top Keywords

skin cancer
24
skin
8
cancer detection
8
deep learning
8
mscd-net model
8
performance proposed
8
isic 2019
8
2019 dataset
8
model
7
cancer
6

Similar Publications

Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy.

Biochem Pharmacol

January 2025

Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou 318000, China. Electronic address:

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent eczematous lesions and severe itching, for which clinical treatments are limited. Selectively inhibiting Janus Kinase 3 (JAK3) and tyrosine kinase expressed in hepatocellular carcinoma (TEC) family kinases is proposed as a promising strategy to treat AD with possible reduced side effects and enhanced efficacy. In this study, we developed a dual JAK3/TEC family kinase inhibitor ZZB, which demonstrated potent inhibitory activity with IC values of 0.

View Article and Find Full Text PDF

Structure-based design of new anticancer N3-Substituted quinazolin-4-ones as type I ATP-competitive inhibitors targeting the deep hydrophobic pocket of EGFR.

Comput Biol Med

January 2025

Drug Design and Discovery Lab, Helmy Institute of Medical Sciences, Zewail City of Science, Technology and Innovation, Giza, 12578, Egypt; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science, Technology and Innovation, Giza, 12578, Egypt. Electronic address:

Epidermal growth factor receptor (EGFR) is amongst the earliest targeted kinases by small-molecule inhibitors for the management of EGFR-positive cancer types. While a few inhibitors are granted FDA approval for clinical use, discovery of new inhibitors is still of merit to enhance ligand-binding stability and subsequent enzyme inhibition. Thus, a structure-based design approach was adopted to devise a new series of twenty-nine N3-substituted quinazolin-4-ones as type I ATP-competitive inhibitors targeting the deep hydrophobic pocket of EGFR.

View Article and Find Full Text PDF

Background: Immune checkpoint inhibitors (ICIs) have been widely applicated for the treatment of patients with advanced esophageal cancer. Skin-related adverse reactions are frequent with ICIs, with toxic epidermal necrolysis (TEN) being a severe and potentially life-threatening cutaneous reaction.

Case Presentation: We present a case of a 70-year-old male with locally advanced esophageal cancer who developed severe toxic epidermal necrolysis (TEN) after 18 days of tislelizumab combined with chemotherapy.

View Article and Find Full Text PDF

Background: Melanoma is the fourth leading cause of cancer-related death worldwide. The continuous exploration and reporting of risk factors of melanoma is important for standardizing and reducing the incidence of the disease. Calcium signaling is a promising therapeutic target for melanoma; however, the relationship between total serum calcium levels and melanoma development remains unclear.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!