AI Article Synopsis
- Pancreatic cancer has a very poor prognosis, primarily due to tumor hypoxia, which is a lack of oxygen in the tumor environment.
- Targeting tumor hypoxia is seen as a promising therapeutic strategy, but past efforts have not achieved clinical success.
- A new compound, NMP-BE@SAC5A, has been developed that effectively targets hypoxic pancreatic cancer cells and has shown significant tumor growth suppression in animal models without causing systemic toxicity.
Article Abstract
The prognosis with pancreatic cancer is among the poorest of any human cancer. One of the important factors is the tumor hypoxia. Targeting tumor hypoxia is considered a desirable therapeutic option. However, it has not been translated into clinical success in the treatment of pancreatic cancer. With enhanced cytotoxicities against hypoxic pancreatic cancer cells, BE-43547A2 (BE) may serve as a promising template for hypoxia target strategy. Here, based on rational modification, a BE prodrug (NMP-BE) is encapsulated into sulfonated azocalix[5]arene (SAC5A) to generate a supramolecular dual hypoxia-responsive complex NMP-BE@SAC5A. Benefited from the selective load release within cancer cells, NMP-BE@SAC5A markedly suppresses tumor growth at low dose in pancreatic cancer cells xenograft murine model without developing systemic toxicity. This research presents a strategy for the modification of covalent compounds to achieve efficient delivery within tumors, a horizon for the realization of safe and reinforced hypoxia target therapy using a simple approach.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500001 | PMC |
| http://dx.doi.org/10.1038/s41467-023-41388-2 | DOI Listing |
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