Let the Guard Down: cAMP Activators Can Improve Immunotherapy in GBM.

Cancer Immunol Res

Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

Published: October 2023

Enhancing T-cell infiltration into glioblastoma (GBM) tumors has proven challenging yet remains crucial for improving the efficacy of immunotherapy for patients with this deadly cancer. In this issue, Qin, Huang, Li, and colleagues find that inhibiting vasculature formation driven by cancer stem cells is a promising target to enhance immunotherapy in GBM. See related article by Qin, Huang, Li, et al., p. 1351 (2).

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Source
http://dx.doi.org/10.1158/2326-6066.CIR-23-0667DOI Listing

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