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Striatal Acetylcholine and Dopamine Interactions Produce Situationappropriate Action Selection. | LitMetric

Striatal Acetylcholine and Dopamine Interactions Produce Situationappropriate Action Selection.

Curr Neuropharmacol

School of Life Sciences, Faculty of Science, University of Technology Sydney, New South Wales 2007, Australia.

Published: June 2024

AI Article Synopsis

  • Individuals learn new actions for specific outcomes while dealing with existing action-outcome associations, leading to potential confusion between what to do in different situations.
  • Research is exploring how the brain, particularly the striatum, resolves this issue by examining the interactions of neurotransmitters like acetylcholine and dopamine, supported by signals from the cortex and thalamus.
  • The review highlights recent findings that contribute to a better understanding of how these neurotransmitters work together to help select appropriate actions based on the current context.

Article Abstract

Individuals often learn how to perform new actions for particular outcomes against a complex background of existing action-outcome associations. As such, this new knowledge can interfere or even compete with existing knowledge, such that individuals must use internal and external cues to determine which action is appropriate to the current situation. The question thus remains as to how this problem is solved at a neural level. Research over the last decade or so has begun to determine how the brain achieves situation-appropriate action selection. Several converging lines of evidence suggest that it is achieved through the complex interactions of acetylcholine and dopamine within the striatum in a manner that relies on glutamatergic inputs from the cortex and thalamus. Here we briefly review this evidence, then relate it to several very recent findings to provide new, speculative insights regarding the precise nature of striatal acetylcholine/dopamine interaction dynamics and their relation to situation- appropriate action selection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097990PMC
http://dx.doi.org/10.2174/1570159X21666230912093041DOI Listing

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