AI Article Synopsis
- - Diagnosing tuberculous pleural effusion (TPE) is difficult due to the limitations of traditional methods like pleural fluid staining, culture, and biopsy, which can be invasive and time-consuming.
- - Nucleic acid amplification tests (NAAT) offer a quicker and less invasive alternative for TPE diagnosis.
- - This review discusses the accuracy of various NAATs for TPE, highlighting findings from systematic reviews and meta-analyses on tests such as GeneXpert and loop-mediated isothermal amplification.
Article Abstract
Diagnosing tuberculous pleural effusion (TPE) is challenging for pulmonologists and laboratory scientists. The gold standards for TPE diagnosis are pleural fluid Ziehl-Neelsen staining, () culture and pleural biopsy. These tools have limitations, including low sensitivity, long turnaround time and invasiveness. The nucleic acid amplification test (NAAT) is a rapid and minimally invasive tool for diagnosing TPE. This review summarizes the diagnostic accuracy of available NAATs for TPE, with a focus on the evidence from systematic reviews and meta-analyses. The NAATs summarized in this review include in-house NAATs, GeneXpert-MTB/RIF, GeneXpert-MTB/RIF Ultra, simultaneous amplification and testing-tuberculosis, FluoroType MTB and loop-mediated isothermal amplification.
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| http://dx.doi.org/10.2217/fmb-2023-0025 | DOI Listing |
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