The pharmacokinetics of cimetidine was studied in 9 patients at a single intravenous (200 mg) and oral (400 mg) administration. The pharmacokinetic parameters at intravenous administration were calculated according to a two-compartment model. The time-concentration curve after oral drug administration had two maxima between 45 min and 2 hrs with approximately equal concentrations of cimetidine. The main pharmacokinetic parameters of cimetidine were calculated as follows: t1/2 beta = 1.7 h, t1/2 alpha = 0.12 h, Vd = 1.0 1/kg, Cis = 0.43 1/kg/h, Cior = 1.2 1/kg/h, bioavailability 36%. At the course treatment (1 g per day) cimetidine concentration before the morning dose on the 6th and 12th days remains at the same level.
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