An antirecurrence effect of theophylline was studied in 32 children aged 3 to 12 years suffering from severe bronchial asthma. The drug dosage was determined by means of a stepwise increase of a daily dose in the range of 10-30 mg/kg/day under control of the patient's general condition and parameters of external respiratory function. Blood theophylline concentration was measured by an immunofluorescent method. The drug individual biotransformation was revealed. Euphylline proved to be a highly effective and safe antirecurrence agent in an individual selection of doses and administration regimens. Combination of theophylline with inhalation beta-adrenomimetics and corticosteroids potentiates its clinical effect without influencing biotransformation.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A highly sensitive photoelectrochemical sensor for the detection of theophylline based on the photoelectrocatalytic activity of a nanocomposite of polydopamine nanospheres and gold nanoparticles.
Anal Methods
January 2025
School of Pharmacy, Wannan Medical College, Wuhu 241002, China.
A label-free photoelectrochemical (PEC) sensor for detecting theophylline (TP) was exploited based on electrodes modified with a nanocomposite of polydopamine nanospheres (PDSs) and gold nanoparticles (AuNPs). PDS particles were prepared by oxidative autopolymerization, and their reducibility was utilized in one step to reduce the gold nanoparticles . The AuNPs-PDS/ZnS PEC sensor was constructed by electrochemical deposition and drop coating.
View Article and Find Full Text PDFHealing Trap States of Anomalous Antisite Defects via Surface Passivation in Lead Iodide Perovskites: A First-Principles Study.
Chemphyschem
January 2025
Department of Physics, Yingbin Road 688, Jinhua, CHINA.
Undesirable loss of open-circuit voltage and current of metal halide perovskite (MHP) solar cells are closely associated with defects, so theoretical calculations have been often performed to scrutinize the nature of defects in bulk of MHPs. Yet, exploring the properties of defects at surfaces of MHPs is severely lacking given the complexity of the surface defects with high concentrations. In this study, IPb (PbI) antisite defects, namely one Pb (I) site being occupied by one I (Pb) atom at the surfaces of the FAPbI3 (FA = CH(NH2)2) material, are found to create electron (hole) traps when the surfaces with IPb (PbI) antisite defects are negatively (positively) charged.
View Article and Find Full Text PDFLooking at the albumin-drug binding via partitioning in aqueous two-phase system.
Biochem Biophys Res Commun
January 2025
Cleveland Diagnostics, 3615 Superior Ave., Cleveland, OH, 44114, USA. Electronic address:
The partition coefficient of human serum albumin (HSA) was analyzed in the PEG600-Dex70, 0.15 M NaCl/KCl in 0.01 M Na/K phosphate buffer, pH 7.
View Article and Find Full Text PDFAminophylline at clinically relevant concentrations affects inward rectifier potassium current in healthy porcine and failing human cardiomyocytes in a similar manner.
Biomed Pharmacother
December 2024
ICRC, St. Anne's University Hospital, Pekařská 53, Brno 602 00, Czech Republic; 1st Department of Internal Medicine, Cardio-Angiology, Faculty of Medicine, Masaryk University, Pekařská 53, Brno 602 00, Czech Republic.
Article Synopsis
- - Aminophylline, a medication often used for severe asthma, can cause arrhythmias, but the exact reasons are not clear
- - In research, aminophylline significantly inhibited the inward rectifier potassium current in both healthy pig heart cells and failing human heart cells at different concentrations
- - The study found that aminophylline prolonged action potential duration in porcine heart cells, indicating its potential role in causing arrhythmias, suggesting further exploration of its effects on other ionic currents is necessary
Experimental and modeling approaches to determine drug diffusion coefficients in artificial mucus.
Heliyon
October 2024
Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, AR, 72701, USA.
Article Synopsis
- Asthma causes inflammation and mucus buildup in the lungs, impacting airflow and making it difficult for orally or inhaled drugs to work effectively.
- This study tested the diffusion of two asthma medications, theophylline and albuterol, through an artificial mucus layer, measuring their concentration over time using special spectroscopy techniques.
- The results yielded diffusion coefficients for the drugs, which matched previous studies, and demonstrated a novel, non-invasive method to evaluate how well drugs can penetrate through complex mucus conditions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!