Sepsis is one of the leading causes of morbidity and mortality in children. Timely recognition and management of sepsis with fluid resuscitation and antibiotic administration leads to better clinical outcomes. However, clinical recognition of sepsis in children is challenging given its rare occurrence, the overlap of clinical features with other common febrile illness, lack of specific diagnostic biomarkers and the ability of children to compensate until the late stages of shock. Despite updating of pediatric sepsis definition and implementation of screening tools to facilitate early recognition, mortality from sepsis continues to be high. Continued education, research and advocacy efforts are needed to improve patient outcomes in pediatric sepsis.
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