AI Article Synopsis
- Tissue-resident macrophages display a variety of metabolic profiles and phenotypes across different organs, with distinct links between metabolic activity and macrophage functions.
- Using advanced flow cytometry, researchers found that metabolic differences correspond to macrophage maturity stages, and helminth infections can alter macrophage activation and metabolism.
- The study highlights the complexity and variability in the metabolic states of macrophages, influenced by both tissue location and immune challenges.
Article Abstract
Tissue-resident macrophage populations constitute a mosaic of phenotypes, yet how their metabolic states link to the range of phenotypes and functions in vivo is still poorly defined. Here, using high-dimensional spectral flow cytometry, we observe distinct metabolic profiles between different organs and functionally link acetyl CoA carboxylase activity to efferocytotic capacity. Additionally, differences in metabolism are evident within populations from a specific site, corresponding to relative stages of macrophage maturity. Immune perturbation with intestinal helminth infection increases alternative activation and metabolic rewiring of monocyte-derived macrophage populations, while resident TIM4 intestinal macrophages remain immunologically and metabolically hyporesponsive. Similar metabolic signatures in alternatively-activated macrophages are seen from different tissues using additional helminth models, but to different magnitudes, indicating further tissue-specific contributions to metabolic states. Thus, our high-dimensional, flow-based metabolic analyses indicates complex metabolic heterogeneity and dynamics of tissue-resident macrophage populations at homeostasis and during helminth infection.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497597 | PMC |
| http://dx.doi.org/10.1038/s41467-023-41353-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Studies on trematodes and acanthocephalans from freshwater fishes of Hubei Province, central China, with the erection of a new genus Quadrihexaspiron gen. n. (Acanthocephala: Neoechinorhynchidae).
Folia Parasitol (Praha)
January 2025
State Key Laboratory of Freshwater Ecology and Biotechnology, and Laboratory of Fish Diseases, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Hubei Province, People's Republic of China *Address for correspondence: Frantisek Moravec, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic. E-mail: ORCID: 0000-0003-1086-1181.
The present paper comprises a systematic survey of trematodes and acanthocephalans based on helminthological examinations of 64 specimens of 14 species of freshwater fishes, belonging to six families of four fish orders, mostly from localities in Hubei Province, central China, collected in the autumn of 2002. A total of 15 trematode species (in 12 families) and 5 acanthocephalan species (in four families) was recorded. Almost all parasites are briefly described and illustrated and problems concerning their morphology, taxonomy, hosts and geographical distribution are discussed.
View Article and Find Full Text PDFConventional and Advanced Methods Used for the Diagnosis of Fascioliosis, a Food-Borne Zoonotic Disease.
J Parasitol Res
January 2025
Department of Parasitology, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Fascioliosis is a food-borne zoonotic helminth infection caused by flatworms belonging to the family Fasciolidae, primarily affecting ruminants. The chronic form of fascioliosis is the most prevalent and is characterized by anemia, weight loss, cirrhosis, and liver dysfunction, along with atrophy, jaundice, and bottle jaw. In humans, infection results in fever, nausea, skin rashes, and severe abdominal pain.
View Article and Find Full Text PDFCommon intestinal parasitic infections in an improved water access, sanitation, and hygiene profile setting in North Jakarta, Indonesia.
Narra J
December 2024
Master of Biomedicine Study Program, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia.
Intestinal parasitic infections (IPIs), caused by helminths and/or protozoa, continue to be a significant public health concern in Indonesia. Water access, sanitation, and hygiene practices (WASH) are influential factors for IPIs, especially among children. The aim of this study was to investigate the association between WASH and IPIs among school-aged children.
View Article and Find Full Text PDFAnalysis of DNA cox1 barcoding revealed novel haplotype in Schistosoma haematobium isolated from Western Sudan.
Sci Rep
January 2025
Faculty of Veterinary Medicine, University of Khartoum, Khartoum, Sudan.
Schistosomiasis poses a significant global health threat, particularly in tropical and subtropical regions like Sudan. Although numerous epidemiological studies have examined schistosomiasis in Sudan, the genetic diversity of Schistosoma haematobium populations, specifically through analysis of the mtcox1 gene, remains unexplored. This study aimed to investigate the risk factors associated with urogenital schistosomiasis among school pupils in El-Fasher, Western Sudan, as well as the mtcox1 genetic diversity of human S.
View Article and Find Full Text PDFIntestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration.
Sci Rep
January 2025
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
As 2030 approaches, the World Health Organization's due date for ending intestinal schistosomiasis as a public health problem in all endemic areas, understanding the current trends in the burden of schistosomiasis among schoolchildren in endemic areas is critical for monitoring the progress, identifying areas for improvement, and developing strategies to plan for instant response to mitigate the burden of schistosomiasis. From February to April of 2023, 328 students from three primary schools in Southwest Ethiopia participated in an institution-based cross-sectional study in the detection of Schistosoma mansoni. Intestinal schistosomiasis was identified among 242 school children, with a rate of infection of 73.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!