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Lack of progress in cancer related outcomes after Liver Transplantation: Mitigating risk & identifying future needs to move this needle.
Liver Transpl
October 2024
Department of Internal Medicine, Mayo Clinic, Rochester MN.
Malignancy has a crucial impact on long-term survival after liver transplantation. There has been enhanced early detection rates with refined cancer screening and improved prognosis for many cancer diagnoses in the general population with the advent of targetted anti-cancer therapies. Similar advancements have not occurred in the transplant population over this same timeframe.
View Article and Find Full Text PDFLeveraging pre-trained machine learning models for islet quantification in type 1 diabetes.
J Pathol Inform
January 2025
Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, Intelligent Critical Care Center, College of Pharmacy, University of Florida, Orlando, FL, USA.
Human islets display a high degree of heterogeneity in terms of size, number, architecture, and endocrine cell-type compositions. An ever-increasing number of immunohistochemistry-stained whole slide images (WSIs) are available through the online pathology database of the Network for Pancreatic Organ donors with Diabetes (nPOD) program at the University of Florida (UF). We aimed to develop an enhanced machine learning-assisted WSI analysis workflow to utilize the nPOD resource for analysis of endocrine cell heterogeneity in the natural history of type 1 diabetes (T1D) in comparison to donors without diabetes.
View Article and Find Full Text PDFProgress in photocatalytic degradation of industrial organic dye by utilising the silver doped titanium dioxide nanocomposite.
Heliyon
December 2024
Mechanical Engineering Department, Faculty of Engineering, Brawijaya University, MT Haryono167, Malang, 65145, Indonesia.
Industrial organic dyes represent a significant portion of pollutants discharged into the environment, particularly by the textile industry. These compounds pose serious threats to living organisms due to their high toxicity. Various techniques have been explored for the degradation of organic dyes, among which heterogeneous photocatalysis utilising titanium dioxide (TiO) stands out as a promising technology.
View Article and Find Full Text PDFIn-Gel and In-Solution Approaches to Protein and Peptide Fractionation.
Methods Mol Biol
December 2024
School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia.
Identifying proteins from living organisms helps us understand the biological functions of cells, discover new molecular mechanisms, and interrogate known mechanisms for improving our understanding. For a comprehensive understanding of cellular functions, identifying the whole protein content, or proteome, of a cell is desirable but challenging. Here, we describe in detail two methods of proteome fractionation at either the protein (SDS-PAGE) or peptide (high-pH reversed-phase fractionation) level, which can be used to maximize the identification of proteins from complex biological samples.
View Article and Find Full Text PDFNonoperative management of rectal cancer.
Front Oncol
December 2024
Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
The management of locally advanced rectal cancer has changed drastically in the last few decades due to improved surgical techniques, development of multimodal treatment approaches and the introduction of a watch and wait (WW) strategy. For patients with a complete response to neoadjuvant treatment, WW offers an opportunity to avoid the morbidity associated with total mesorectal excision in favor of organ preservation. Despite growing interest in WW, prospective data on the safety and efficacy of nonoperative management are limited.
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