AI Article Synopsis
- Proton pump inhibitors (PPIs) are widely prescribed medications used for treating gastric acid-related disorders, but concerns about inappropriate usage have emerged over the years.
- There are worries regarding the safety and adverse effects of long-term PPI use, emphasizing the need for better management practices known as PPI stewardship.
- The Indian Society of Gastroenterology has developed guidelines using a modified Delphi process to optimize PPI use and enhance clinician awareness on appropriate indications and durations for prescribing them.
Article Abstract
Proton pump inhibitors (PPIs) have been available for over three decades and are among the most commonly prescribed medications. They are effective in treating a variety of gastric acid-related disorders. They are freely available and based on current evidence, use of PPIs for inappropriate indications and duration appears to be common. Over the years, concerns have been raised on the safety of PPIs as they have been associated with several adverse effects. Hence, there is a need for PPI stewardship to promote the use of PPIs for appropriate indication and duration. With this objective, the Indian Society of Gastroenterology has formulated guidelines on the rational use of PPIs. The guidelines were developed using a modified Delphi process. This paper presents these guidelines in detail, including the statements, review of literature, level of evidence and recommendations. This would help the clinicians in optimizing the use of PPIs in their practice and promote PPI stewardship.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12664-023-01428-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Crises in Antimicrobial Stewardship: Misuse of Clarithromycin for Therapy.
Pharmacoepidemiology
March 2024
Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine Houston, 2002 Holcombe Blvd (111D), Houston, TX 77030, USA.
is a class I carcinogen that infects more than 100 million individuals in the United States. Antimicrobial therapy for has typically been prescribed empirically rather than based on susceptibility testing. Until recently, therapeutic recommendations have generally ignored the principles of antibiotic stewardship.
View Article and Find Full Text PDFProton pump inhibitor effect on macrophage and neutrophil function: a systematic review.
Front Immunol
January 2025
College of Pharmacy, University of Houston, Houston, TX, United States.
Background: Proton pump inhibitors (PPIs) are one of the most used drugs worldwide. While generally considered safe, the usage of PPIs is associated with several adverse outcomes including acute infectious diseases. PPIs influence macrophage and neutrophil function although a systematic review has never been undertaken.
View Article and Find Full Text PDFIncidence, Clinical Characteristics, and Outcomes of Clostridium difficile Infection in a Tertiary Care Center in Bahrain.
Cureus
April 2024
Pharmacy, Salmaniya Medical Complex, Manama, BHR.
Background infection (CDI) represents a significant healthcare challenge associated with antibiotic use and healthcare settings. While healthcare facility-onset CDI (HO-CDI) rates have been extensively studied, the incidence and risk factors of CDI in various settings, including the community, require further investigation. Aim This study aims to examine the incidence rates of CDI in a major governmental hospital in Bahrain, identify risk factors for CDI, and assess the effectiveness of infection control measures.
View Article and Find Full Text PDFProton pump inhibitors increase the risk of carbapenem-resistant Enterobacteriaceae colonization by facilitating the transfer of antibiotic resistance genes among bacteria in the gut microbiome.
Gut Microbes
April 2024
Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of Korea.
Carbapenem-resistant Enterobacteriaceae (CRE) pose a global health threat; however, there is still limited understanding of the risk factors and underlying mechanisms of CRE colonization in the gut microbiome. We conducted a matched case-control study involving 282 intensive care unit patients to analyze influencing covariates on CRE colonization. Subsequently, their effects on the gut microbiome were analyzed in a subset of 98 patients (47 CRE carriers and 51 non-CRE carriers) using whole metagenome sequences.
View Article and Find Full Text PDFProton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis.
Saudi Pharm J
December 2023
Department of Epidemiology and Biostatistics, College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Introduction: Proton pump inhibitors (PPIs) show a high level of efficacy and a high safety profile, and they have been increasingly prescribed in recent years. However, recent pharmacoepidemiological evidence has shown that PPI use has been associated with health risks and complications.
Objectives: This study aimed to assess the prescribing patterns of proton pump inhibitors and the prevalence of potential drug-drug interactions (DDIs) among patients who use PPIs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!