AI Article Synopsis

  • A study was conducted using a large population database to analyze pregnancy outcomes for women with Down syndrome (DS) from 2004 to 2014, comparing them to a control group of women without DS.* -
  • Out of over 9 million deliveries, only 184 were identified with mothers having DS; the study found that while many pregnancy outcomes were similar, women with DS had a significantly higher risk of prematurity and adverse neonatal conditions.* -
  • The authors recommend that women with DS receive counseling about these risks and enhance antenatal monitoring to address the potential complications for both mothers and newborns.*

Article Abstract

Purpose: We utilized a population database to address the paucity of data around pregnancy outcomes in women with Down syndrome (DS).

Methods: We conducted a retrospective study using the Health Care Cost and Utilization Project-Nationwide Inpatient Sample Database over 11 years, from 2004 to 2014. A delivery cohort was created using ICD-9 codes. ICD-9 code 758.0 was used to extract the cases of maternal DS. Pregnant women with DS (study group) were matched based on age, race, income, and health insurance type to women without DS (control) at a ratio of 1:20.

Results: There were a total of 9,096,788 deliveries during the study period. Of those, 184 pregnant women were found to have DS. The matched control group was 3680. After matching, most of the pregnancy and delivery outcomes, such as pregnancy-induced hypertension, gestational diabetes, preterm premature rupture of membrane, chorioamnionitis, cesarean section, operative vaginal delivery, or blood transfusion were similar between participants with and without DS. However, patients with DS were at increased risk of giving birth prematurely (aOR 3.09, 95% CI 2.06-4.62), and having adverse neonatal outcomes such as small for gestational age (aOR 2.70, 95% CI 1.54-4.73), intrauterine fetal demise (aOR 22.45, 95% CI 12.02-41.93), congenital anomalies (aOR 7.92, 95% CI 4.11-15.24), and fetal chromosomal abnormalities.

Conclusion: Neonates to mothers with DS are at increased risk of prematurity and other neonatal adverse outcomes. Hence, counseling patients with DS about these risks and increased antenatal surveillance is advised.

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Source
http://dx.doi.org/10.1007/s00404-023-07208-0DOI Listing

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