AI Article Synopsis
- Blood microbiota in HIV-infected individuals is not well understood, even though their gut microbiota shows changes.
- Evidence suggests that HIV-infected individuals have greater diversity in their blood microbiota, possibly due to gut microbes moving into the bloodstream.
- Certain microbes have been identified that are associated with inadequate immune recovery, laying the groundwork for potential therapies aimed at improving immune function in HIV patients.
Article Abstract
The characteristics of blood microbiota in HIV-infected individuals and their relevance to disease progression are still unknown, despite alterations in gut microbiota diversity and composition in HIV-infected individuals. Here, we present evidence of increased blood microbiota diversity in HIV-infected individuals, which may result from gut microbiota translocation. Also, we identify a group of microbes, , sp. , sp. , , , sp. , and , which are linked to poor immunological recovery. This work provides a scientific foundation toward therapeutic strategies targeting blood microbiota for immune recovery of HIV infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654078 | PMC |
| http://dx.doi.org/10.1128/msystems.00467-23 | DOI Listing |
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