AI Article Synopsis
- Helicobacter pylori (HP) eradication is generally advised after treating early gastric cancer (EGC) with surgery, but there’s uncertainty about its necessity due to reports of spontaneous HP resolution post-surgery.
- A study followed 80 gastric cancer patients who underwent partial gastrectomy from 2016 to 2020, finding that 42.5% experienced spontaneous clearance of HP within a year.
- The use of proton pump inhibitors (PPIs) was associated with higher rates of HP resolution, though the type of surgical reconstruction didn’t significantly affect HP disappearance rates.
Article Abstract
Background/aims: Helicobacter pylori (HP) eradication is recommended after endoscopic treatment of early gastric cancer (EGC). Cases of spontaneous HP resolution after partial gastrectomy due to environmental changes have been reported; however, there is no evidence for the efficacy of HP eradication in suppressing carcinogenesis and also no reports on the natural history of HP after partial gastrectomy in gastric cancer (GC). To report the natural history of HP in patients with GC and HP infection after partial gastrectomy.
Methods And Results: We prospectively studied the rate of spontaneous disappearance of HP after partial gastrectomy in patients with GC. From April 2016 to May 2020, 80 patients underwent partial gastrectomy, including 9 cases of proximal gastrectomy (PG), and 71 cases of distal gastrectomy (DG). The presence of HP was confirmed in the stool antigen test 1 year after operation, HP infection persisted in 46 patients (57.5%) and disappeared in 34 patients (42.5%). In univariate analysis, only proton pump inhibitor (PPI) use was a significant contributing factor for the spontaneous resolution of HP infection, especially in the DG group. However, there was no difference in the rates of HP disappearance between Billroth-I and Roux-en-Y reconstructions in the DG group.
Conclusion: The HP spontaneously disappeared in 42.5% of the GC patients within 1 year after partial gastrectomy. Further investigation in a larger cohort is needed to elucidate the underlying mechanisms.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10728519 | PMC |
| http://dx.doi.org/10.1002/cnr2.1903 | DOI Listing |
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