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Striving for clarity in language about gene expression.
Nucleic Acids Res
October 2024
Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
What do we mean when we say 'gene expression'? In the decades following Crick's 1958 central dogma of molecular biology, whereby genetic information flows from DNA (genes) to RNA (transcripts) to protein (products), we have learned a great deal about DNA, RNA, proteins, and the ensuing phenotypic changes. With the advent of high-throughput technologies (1990s), molecular biologists and computer scientists forged critical collaborations to understand the vast amount of data being generated, rapidly escalating gene expression research to the 'omics' level: entire sets of genes (genomes), transcribed RNAs (transcriptomes), and synthesized proteins (proteomes). However, some concessions came to be made for molecular biologists and computer scientists to understand each other-one of the most prevalent being the increasingly widespread use of 'gene' to mean 'RNAs originating from a DNA segment'.
View Article and Find Full Text PDFReply to 'When linguistic dogma rejects a neuroscientific hypothesis'.
Nat Rev Neurosci
November 2023
Max Planck Institute for Empirical Aesthetics, Frankfurt, Germany.
When linguistic dogma rejects a neuroscientific hypothesis.
Nat Rev Neurosci
November 2023
Research Group Language Cycles, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
A concept analysis was performed on surgical conscience in perioperative nursing using the Penrod and Hupcey principle-based method. The analysis included framing surgical conscience according to the epistemological, pragmatic, linguistic, and logical principles and showed that surgical conscience falls into several domains, including nursing, surgery, anesthesiology, surgical technology, and interventional radiology. Although some perioperative nurses consider surgical conscience a fundamental principle in the OR, there is limited published literature on how surgical conscience is introduced, learned, improved, or measured.
View Article and Find Full Text PDFProbiotics in health and disease: fooling Mother Nature?
Infection
December 2019
Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore.
Probiotics are ubiquitous, consumption by the general public is common, and the dogma remains that they are beneficial for general and gut health. However, evolving evidence suggests a potentially "harmful" impact of many commercially available probiotics. There is also significant variability in formulations that leads to a lack of a universally acceptable definition of probiotics.
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