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http://dx.doi.org/10.1001/jamapediatrics.2023.3229 | DOI Listing |
Microbiol Spectr
January 2025
Department of Microbiology and Immunology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, Alabama, USA.
Unlabelled: Bioluminescence imaging (BLI) using engineered bioluminescent viruses has emerged as a powerful tool for real-time, noninvasive monitoring of viral replication in living animals. While traditional luciferase-based systems, such as firefly luciferase, have been widely used, the NanoLuc luciferase system offers distinct advantages, including its significantly smaller gene size, increased brightness, and independence from ATP as a cofactor, allowing for extracellular detection. However, the utility of NanoLuc has been limited by its traditional substrate, furimazine, which exhibits poor water solubility and potential cytotoxicity.
View Article and Find Full Text PDFSci Rep
January 2025
School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
Lighting systems account for a significant proportion of energy consumption in buildings. Therefore, energy conservation within these systems can greatly enhance overall building energy efficiency. This study proposes a control strategy for LED lamps by adjusting lighting intensity and improving the performance of electric luminaires.
View Article and Find Full Text PDFLancet
January 2025
Francis I Proctor Foundation, University of California San Francisco, San Francisco, CA, USA; Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA; Institute for Global Health Sciences, University of California San Francisco, San Francisco, CA, USA.
Background: Adalimumab is an effective treatment for juvenile idiopathic arthritis-associated uveitis. Data are scarce on the effects of discontinuing adalimumab after control of the disease had been reached. We aimed to assess efficacy and safety of discontinuing treatment in patients with juvenile idiopathic arthritis-associated uveitis.
View Article and Find Full Text PDFPlants (Basel)
January 2025
Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche (UNIVPM), Via Brecce Bianche 10, 60131 Ancona, Italy.
Water scarcity is an ecological issue affecting over 10% of Europe. It is intensified by rising temperatures, leading to greater evaporation and reduced precipitation. Agriculture has been confirmed as the sector accounting for the highest water consumption globally, and it faces significant challenges relating to drought, impacting crop yields and food security.
View Article and Find Full Text PDFPediatr Infect Dis J
January 2025
From the Division of Infectious Diseases.
Background: Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) can improve adherence among adolescents and youth with HIV (AYHIV). We evaluated LAI CAB/RPV treatment outcomes among AYHIV.
Methods: An observational cohort study of AYHIV <25 years initiated LAI CAB/RPV from October 2021 to June 2024 as a standard of care.
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