Behav Brain Sci
Departments of Philosophy and Integrative Biology, University of Texas at Austin, Austin, TX,
Published: September 2023
Polygenic score (PGS) computations assume an additive model of gene action because associations between phenotypes and alleles at different loci are compounded, ignoring interactions between alleles or loci let alone between genotype and environment. Consequently, PGSs are subject to the same objections that invalidated traditional heritability analyses in the 1970s. Thus, PGSs should not be used in the social sciences.
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http://dx.doi.org/10.1017/S0140525X22002321 | DOI Listing |
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