Modification of allergen subcutaneous immunotherapy safety precautions and systemic allergic reaction rate reduction.

Despite their life-threatening potential, medical team mistakes during subcutaneous immunotherapy are rarely discussed. Real data are missing, and a survey study estimated that dosing errors are responsible for 25% of systemic reactions during immunotherapy. To minimize errors, we modified our safety precautions and compared the rates of systemic allergic reactions before and after the change. Our retrospective comparative cohort study compared systemic allergic reaction rates during 2012-2015 and 2016-2019, after a second check of the injected allergen/s by another nurse/physician was added to the treatment protocol. The rate of systemic allergic reaction per injection was reduced from 0.93 to 0.71%; p = 0.023. A second check prior to injection is beneficial and can reduce the allergic reaction rate during immunotherapy.