Aim The aim of the study was to evaluate the long-term effect of large horizontal rectus muscle recession on macula thickness using spectral domain optical coherence tomography (SD-OCT). Material and methods Forty-two children were included in the study. The intervention groups were the medial rectus (MR) group (=20 eyes ) and the lateral rectus (LR) group (=22 eyes), including the eyes that underwent large medial and lateral rectus muscle recession, respectively. The control group included the fellow 42 unoperated eyes of the same children. Each eye was scanned using Topcon Maestro2 OCT-Angiography (OCTA; Topcon, Tokyo, Japan) preoperatively and then two months following surgery. A paired t-test was used to compare the mean difference in macular thickness between the intervention and control groups using the statistical program R (R Foundation for Statistical Computing, Vienna, Austria). Results The mean change in central, parafoveal, and perifoveal macular thickness of the intervention group was not statistically significant. Conclusion The long-term changes in macular thickness, as evaluated using SD-OCT both for the central and peripheral regions of the fovea, following large horizontal rectus muscle recession surgery, are not statistically significant.
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http://dx.doi.org/10.7759/cureus.43145 | DOI Listing |
Alzheimers Dement
December 2024
Ophthalmology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea, Republic of (South).
Background: Spectrum Domain-Optical Coherence Tomography (SD-OCT) is a non-invasive technology that acquires cross-sectional images of retinal structures allowing neural fundus integrity assessment. Macular thickness and retinal nerve fiber layer (RNFL) thickness measured by an SD-OCT have been used as a indicator of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However which portion of retinal RNFL is the most sensitive area among normal control, aMCI and AD is not clear yet.
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December 2024
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Background: The early detection of preclinical dementia is crucial, prompting investigations into retinal biomarkers using optical coherence tomography (OCT). Inconsistent and limited longitudinal studies have been done to clarify the association between the retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness and cognitive function over time. This study aims to explore the association between retinal biomarkers and cognitive function over time in non-demented older adults.
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December 2024
D- NO Visual Therapy Center, Istanbul, Turkey; Uskudar University, İstanbul, Turkey.
Background: Alzheimer's Disease (AD) is a chronic neurodegenerative disease characterized by loss of memory and cognitive decline associated with an increase in ß-amyloid (Aß) plaque deposition, neurofibrillary tangle formation (NFT) and inflammation. Fundus Autofluorescein (FAF) can detect lipofuscin secreted by misfolded plaques during the neurodegeneration process. And Optical Scanning Tomography ( OCT ) is able to find out the retinal layers of the accumulation ( inner retinal layers in AD ).
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December 2024
University of Alabama at Birmingham, Birmingham, AL, USA.
Background: The potential of plasma Aβ42/Aβ40 ratio, NfL, p-tau 181, and p-tau 217 has been extensively discussed in the literature. Our previous study explored the association between retinal biomarkers and preclinical AD. The goal of this study was to evaluate the association and a multimodal model of retinal and plasma biomarkers for detection of preclinical AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
West China Hospital of Sichuan University, Chengdu, China.
Background: Alzheimer's disease (AD) and Frontotemporal dementia (FTD) are the two most common causes of early-onset dementia. Differentiating between AD and FTD can be challenging due to overlapping cognitive and behavioral manifestations. However, evidence on non-invasive and early-stage biomarkers for differentiating AD and FTD is still limited.
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