AI Article Synopsis
- The CRISPR/Cas9 system is a natural immune mechanism found in bacteria and archaea, consisting of specific loci, genes, and proteins that can identify and cut foreign DNA.* -
- The Cas9 protein acts as a nuclease, enabling precise DNA modifications like base insertion or deletion through DNA repair processes.* -
- Recent research highlights the potential of CRISPR/Cas9 for treating neurological diseases, making it a promising candidate for clinical applications in gene editing.*
Article Abstract
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system is an acquired immune system of many bacteria and archaea, comprising loci, genes, and its associated proteins. This system can recognize exogenous DNA and utilize the Cas9 protein's nuclease activity to break DNA double-strand and to achieve base insertion or deletion by subsequent DNA repair. In recent years, multiple laboratory and clinical studies have revealed the therapeutic role of the CRISPR/Cas9 system in neurological diseases. This article reviews the CRISPR/Cas9-mediated gene editing technology and its potential for clinical application against neurological diseases.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491921 | PMC |
| http://dx.doi.org/10.1016/j.gendis.2023.03.017 | DOI Listing |
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