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| http://dx.doi.org/10.1093/hr/uhad149 | DOI Listing |
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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Recent genetic studies have implicated >70 genomic loci associated with the risk for Alzheimer's Disease. However, the underlying functional mechanisms remain unclear. Several functional genomics (FG) methods such as chromosome conformation (CC) capture technologies and expression quantitative trait loci (eQTLs) have been developed to study the genetic targets.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Background: The integration of quantitative trait loci (QTLs) with disease genome-wide association studies (GWAS) has proven successful at prioritizing candidate genes at disease-associated loci. Most of QTL studies are focusing on expression QTLs in plasma and brain and cis-signals.
Method: Here we analyzed a large proteomic (Somalogic 7K) and metabolomic (Metabolon HD4) CSF (n = 3, 000) and plasma (African (AFR, N = 400) and European (EUR, N = 2,300) ancestry, respectively) to identify novel QTLs.
Advancing crop improvement through GWAS and beyond in mung bean.
Front Plant Sci
December 2024
Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Science (NIAB-C, PIEAS), Faisalabad, Pakistan.
Accessing the underlying genetics of complex traits, especially in small grain pulses is an important breeding objective for crop improvement. Genome-wide association studies (GWAS) analyze thousands of genetic variants across several genomes to identify links with specific traits. This approach has discovered many strong associations between genes and traits, and the number of associated variants is expected to continue to increase as GWAS sample sizes increase.
View Article and Find Full Text PDFOverview of research on virus-resistant breeding of melon.
Front Plant Sci
December 2024
Horticultural Research Institute and Shanghai Key Lab of Protected Horticultural Technology, Shanghai Academy of Agricultural Sciences, Shanghai, China.
The development of virus-resistant melon varieties not only poses challenges in balancing melon quality and resistance but also contributes to sustainable agricultural development. This research focuses on the exploration and application of various breeding techniques to enhance the virus resistance of melon varieties. Molecular markers associated with virus resistance genes have been identified and utilized in marker-assisted selection, enabling more efficient and targeted breeding.
View Article and Find Full Text PDFWhy usefulness is rarely useful.
G3 (Bethesda)
December 2024
Department of Plant Sciences, University of California Davis, Davis, CA 95616, USA.
Mate selection plays an important role in breeding programs. The Usefulness Criterion was proposed to improve mate selection, combining information on both the mean and standard deviation of the potential offspring of a cross, particularly in clonally propagated species where large family sizes are possible. Predicting the mean value of a cross is generally easier than predicting the standard deviation, especially in outbred species when the linkage of alleles is unknown and phasing is required.
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