AI Article Synopsis
- Many bacteria form biofilms, which are clusters that allow them to survive tough environmental conditions and resist antibiotics, linking them to disease development.
- Within these biofilms, bacteria can exhibit different behaviors and characteristics, indicating that they can act more like a community than as isolated single cells.
- This article summarizes research on Clostridium perfringens, focusing on its biofilm structures, gene expression related to its virulence, and how it interacts with host organisms through vesicles.
Article Abstract
Many bacteria form biofilms and survive in the actual environment. Biofilms are not only a major form of bacteria but are also involved in tolerance to environmental stresses and antibiotics, suggesting the association with bacterial pathogenesis. Cells within biofilms display phenotypic heterogeneity; thus, even bacteria, unicellular organisms, can functionally differentiate and show multicellular behavior. Therefore, it is necessary to understand bacteria as a population to control their survival and pathogenesis in the actual environment. Previously, we found that Clostridium perfringens, an anaerobic pathogenic bacterium, form different structures in different temperatures and phenotypic heterogeneity on biofilm matrix gene expression within the biofilm. In this article, I summarize the results of our research on biofilms and their heterogeneity, the mechanisms of post-transcriptional gene expression regulation of virulence genes, and bacteria-host interactions mediated by extracellular membrane vesicles.
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| http://dx.doi.org/10.3412/jsb.78.159 | DOI Listing |
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