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Establishment and validation of a prognostic model for idiopathic pulmonary fibrosis based on mitochondrial-related genes.
J Thorac Dis
November 2024
Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Key Cite of National Clinical Research Center for Respiratory Disease, Wuhan Clinical Medical Research Center for Chronic Airway Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Background: The prognosis for patients diagnosed with idiopathic pulmonary fibrosis (IPF) is exceedingly grim, and there are currently no pharmacological interventions available that effectively reduce mortality rates. Emerging evidence underscores the intimate connection between mitochondrial dysfunction and the onset and advancement of IPF. However, there remains a scarcity of prognostic models for assessing the risk associated with mitochondrial-related genes in IPF.
View Article and Find Full Text PDFYAP Promotes Chemoresistance to 5-FU in Colorectal Cancer Through mTOR/GLUT3 Axis.
J Cancer
November 2024
Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Although chemoresistance constitutes a significant barrier to the effectiveness of chemotherapy in colorectal cancer (CRC), its precise mechanisms remain unclear. YAP functions as an oncogene in various malignancies. However, the relationship between YAP and chemoresistance in CRC needs clarification.
View Article and Find Full Text PDFWTAP-Mediated mA Modification of circSMOC1 Accelerates the Tumorigenesis of Non-Small Cell Lung Cancer by Regulating miR-612/CCL28 Axis.
J Cell Mol Med
December 2024
Department of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, China.
Accumulating evidence reveals that deregulated N6-methyladenosine (mA) RNA methylation and circular RNAs (circRNAs) are required for the tumorigenesis of non-small cell lung cancer (NSCLC). We aimed to uncover the underlying mechanisms by which WTAP-mediated mA modification of circRNA contributes to NSCLC. The differentially-expressed circRNAs were identified by a circRNA profiling microarray.
View Article and Find Full Text PDFUnveiling the clinicopathological enigma of crawling-type gastric adenocarcinoma.
World J Gastrointest Oncol
November 2024
Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, Larissa 41110, Greece.
In this editorial we comment on the article by Xu . Gastric adenocarcinoma (GA) is a malignancy which arises from the gastric mucosa and encompasses heterogenous tumors with varying characteristics. There are two main classifications: Lauren's and the World Health Organization distinguishing the diverse types of GA depending on clinical, genetic, morphological and epidemiological features.
View Article and Find Full Text PDFDeciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis.
iScience
November 2024
Department of Minimally Invasive Esophageal Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
In this study, we delved into the intrinsic cellular components and transcriptomic signatures characterizing breast-invasive micropapillary carcinoma (IMPC). Employing bulk RNA sequencing, we conducted differential gene expression and functional profiles across breast cancer tissues. Single-cell transcriptome sequencing was performed on mixed IMPC samples.
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