How vitamins act as novel agents for ameliorating diabetic peripheral neuropathy: A comprehensive overview.

Ageing Res Rev

Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China; First School of Clinical Medicine, Wenzhou Medical University, Wenzhou, PR China. Electronic address:

Published: November 2023

AI Article Synopsis

  • Diabetic peripheral neuropathy (DPN) is a common and debilitating complication of diabetes, with limited effective treatment options available.
  • Researchers are exploring the potential role of vitamins in diagnosing and treating DPN, though their exact impact is still unclear.
  • This review analyzes existing studies on vitamins and DPN, highlighting the potential for vitamin-based therapies as a new avenue for treatment.

Article Abstract

Diabetic peripheral neuropathy (DPN) is a pervasive and incapacitating sequela of diabetes, affecting a significant proportion of those diagnosed with the disease, yet an effective treatment remains elusive. Vitamins have been extensively studied, emerging as a promising target for diagnosing and treating various systemic diseases, but their role in DPN is not known. This review collates and synthesizes knowledge regarding the interplay between vitamins and DPN, drawing on bibliographies from prior studies and relevant articles, and stratifying the therapeutic strategies from prophylactic to interventional. In addition, the clinical evidence supporting the use of vitamins to ameliorate DPN is also evaluated, underscoring the potential of vitamins as putative therapeutic agents. We anticipate that this review will offer novel insights for developing and applying vitamin-based therapies for DPN.

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Source
http://dx.doi.org/10.1016/j.arr.2023.102064DOI Listing

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