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Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review. | LitMetric

AI Article Synopsis

  • Phytochemicals, or secondary metabolites found in fruits, vegetables, and grains, play a significant role in health despite being classified as non-essential nutrients, as they have medicinal properties that can help prevent and treat diseases.* -
  • Dietary polyphenols, including compounds like kaempferol, quercetin, and resveratrol, offer various health benefits such as regulating oxidation, modulating blood vessel function, and reducing inflammation, which can contribute to heart health.* -
  • Current research emphasizes the protective effects of polyphenols against cardiovascular disorders and related conditions, suggesting that a diet rich in these compounds could lower the risk of heart diseases like hypertension and strokes.*

Article Abstract

Fruits, vegetables, and other food items contain phytochemicals or secondary metabolites which may be considered non-essential nutrients but have medicinal importance. These dietary phytochemicals exhibit chemopreventive and therapeutic effects against numerous diseases. Polyphenols are secondary metabolites found in vegetables, fruits, and grains. These compounds exhibit several health benefits such as immune modulators, vasodilators, and antioxidants. This review focuses on recent studies on using dietary polyphenols to treat cardiovascular disorders, atherosclerosis, and vascular endothelium deficits. We focus on exploring the safety of highly effective polyphenols to ensure their maximum impact on cardiac abnormalities and discuss recent epidemiological evidence and intervention trials related to these properties. Kaempferol, quercetin, and resveratrol prevent oxidative stress by regulating proteins that induce oxidation in heart tissues. In addition, polyphenols modulate the tone of the endothelium of vessels by releasing nitric oxide (NO) and reducing low-density lipoprotein (LDL) oxidation to prevent atherosclerosis. In cardiomyocytes, polyphenols suppress the expression of inflammatory markers and inhibit the production of inflammation markers to exert an anti-inflammatory response. Consequently, heart diseases such as strokes, hypertension, heart failure, and ischemic heart disease could be prevented by dietary polyphenols.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490098PMC
http://dx.doi.org/10.3390/molecules28176403DOI Listing

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