AI Article Synopsis
- The research focuses on creating new organic reactions that are efficient in atom economy and highly selective, particularly using propargylamines as a key component.
- Successful palladium-catalyzed and base-promoted reactions lead to the formation of functionalized quinoline heterocycles and diverse 1-azadienes, achieving high yields (up to 93%) and good tolerance for various functional groups.
- The resulting compounds from these reactions are valuable and can be easily transformed into other useful materials, demonstrating the effectiveness of these selective reactions.
Article Abstract
Developing new organic reactions with excellent atom economy and high selectivity is significant and urgent. Herein, by ingeniously regulating the reaction conditions, highly selective transformations of propargylamines have been successfully implemented. The palladium-catalyzed cyclization of propargylamines generates a series of functionalized quinoline heterocycles, while the base-promoted isomerization of propargylamines affords diverse 1-azadienes. Both reactions have good functional group tolerance, mild conditions, excellent atom economy and high yields of up to 93%. More importantly, these quinoline heterocycles and 1-azadienes could be flexibly transformed into valuable compounds, illustrating the validity and practicability of the propargylamine-based highly selective reactions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488633 | PMC |
| http://dx.doi.org/10.3390/molecules28176259 | DOI Listing |
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